MIR24-2

Summary

MIR24-2 (microRNA 24-2, HGNC:31608) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407013 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31608
Approved symbol	MIR24-2
Name	microRNA 24-2
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-24-2
Ensembl gene	ENSG00000284387
Ensembl biotype	miRNA
OMIM	610724
Entrez	407013
RNAcentral	URS00000FFC8B — miRNA, 73 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000386972

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000386972 — 1 exons

Exon	Start	End
ENSE00001501978	13836287	13836359

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 97.09.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.09	gold quality
spleen	UBERON:0002106	71.98	gold quality
blood	UBERON:0000178	67.08	gold quality
right atrium auricular region	UBERON:0006631	64.93	gold quality
tibial artery	UBERON:0007610	64.00	gold quality
substantia nigra	UBERON:0002038	61.81	gold quality
skin of leg	UBERON:0001511	60.70	gold quality
gastrocnemius	UBERON:0001388	59.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.48	gold quality
tibial nerve	UBERON:0001323	56.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	55.86	gold quality
transverse colon	UBERON:0001157	54.30	gold quality
esophagus mucosa	UBERON:0002469	54.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.54	gold quality
left lobe of thyroid gland	UBERON:0001120	52.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.03	gold quality
colon	UBERON:0001155	51.80	gold quality
skin of abdomen	UBERON:0001416	50.76	gold quality
omental fat pad	UBERON:0010414	45.56	gold quality
right frontal lobe	UBERON:0002810	44.69	gold quality
prostate gland	UBERON:0002367	42.69	gold quality
thoracic mammary gland	UBERON:0005200	39.83	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-23a, 27a, and 24-2 upregulation induces caspase-dependent and -independent apoptosis in human embryonic kidney cells (PMID:19513126)
• Data show that miR-24 regulates apoptosis by targeting FAF1 in cancer cells. (PMID:20195546)
• Study show thatb miRNAs of miR-23a27a24-2 cluster in relation to various health and diseased conditions and highlight the cooperative effects of the miRNAs of this cluster. (PMID:20815877)
• study provides evidence for role of miR-24-2 in guiding H2AFX gene expression in the background of the differential status of gene copy number; study identifies antiapoptotic gene BCL-2 as a cellular target of miR-24-2 and provides mechanistic insight into the apoptotic induction caused by miR-24-2 overexpression (PMID:21463514)
• Taken together, this work underlines the role of ER stress in miR-23a27a24-2 cluster mediated apoptosis in HEK293T cells. (PMID:21593605)
• miR-24 is a direct regulator of ST7L. (PMID:23142218)
• SON protein regulates GATA-2 through transcriptional control of the microRNA 23a27a24-2 cluster (PMID:23322776)
• Data suggest epidermal growth factor induced the expression of c-MYC, which promoted the expression of mature miR-23a, miR-24-2, and miR-27a and subsequently decreased expression of Sprouty2 (SPRY2). (PMID:23649631)
• expression of miR-24-3p mediates plasma cell survival (PMID:23934711)
• Human mir-24 is an inhibitor of smooth muscle cell proliferation, contributing to loss of vascularization. (PMID:24063572)
• We disclosed herein a new role of the senescence marker p16INK4a and its regulation by miR-24 during osteoarthritis and terminal chondrogenesis. (PMID:24572376)
• miR-24 promotes renal ischemic injury by stimulating apoptosis in endothelial and tubular epithelial cells (PMID:24854275)
• findings support a lung metastasis-promoting function of the miR-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer (PMID:24966325)
• Our findings defined a central role for miR24 as a tumor-suppressive miRNA in NPC and suggested its use in novel strategies for treatment of this cancer. (PMID:25319395)
• conclude that miR-24-3p regulates autophagy by targeting ATG4A (PMID:25426560)
• Down-regulation of miR-24-3p contributes to the development and progression of colorectal cancer (PMID:25502080)
• These findings implicated that miR-24 high regulation is a common event in acute myeloid leukemia with t(8;21). (PMID:25550847)
• these results demonstrate that miR-24, miR-30b, and miR-142-3p regulate phagocytosis and associated cytokine production in myeloid inflammatory cells through modulation of various genes involved in the pathway. (PMID:25601927)
• Human miR-24-2 targets genes essential for initiating cellular stability and cell survival. (PMID:25943634)
• Data show that miR-24-3p is up-regulated and an important regulator in breast cancer, and imply that the miR-24-3p/p27Kip1 axis has potential as a therapeutic target for breast cancer. (PMID:26044523)
• study found frequent high expression of miR-24 in gastric cancer in high-dose-exposed atomic bomb survivors (PMID:26045155)
• miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in a model of pancreatic carcinoma (PMID:26517093)
• miR-24-3p, miR-151a-5p, and miR-425-5p have been identified as the most valid combination of reference genes for microRNA RT-qPCR studies in a hepatitis B virus replicating HepG2 cell model. (PMID:26801621)
• These findings provide evidence that miR-24 has a tumor suppressor role in prostate cancer and also targets p27 and p16 in prostate cancer cells (PMID:26847530)
• This study suggests that miR-34a-3p/5p, miR-141-3p/5p, and miR-24 in decidual natural killer cells could be associated with Unexplained Recurrent Spontaneous Abortion. (PMID:26996957)
• we predicted CG-rich region of miR-23a-27a-24-2 cluster (miR-23a, miR-27a, and miR-24-2)promoter and detected the methylation status in the region spanning two SP1 sites. (PMID:27099864)
• Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). (PMID:27538493)
• miR-24-3p was identified as a regulator of development and progression of H. pylori-related gastric mucosal lesions. Gain- or loss-of-function experiments showed that miR-24-3p significantly inhibited N87 cell growth, migration, and invasion and promoted apoptosis. (PMID:27743162)
• miR-24 functions as an oncogene in hepatocellular carcinoma, at least partly by promoting cell invasion through down-regulation of p53. (PMID:27780140)
• miR-24-3p overexpression is a potentially unfavorable prognosticator for patients who were not treated with radiotherapy (PMID:27939727)
• These results demonstrate that miR-24 may be a central regulator of key events that contribute to race-related tumorigenesis in prostate cancer. (PMID:28157714)
• the expression levels of miR-19b, miR-24, and miR-195 in serum may be useful for the diagnosis of Parkinson’s disease (PMID:28223160)
• miR-24-3p Is overexpressed in Hodgkin lymphoma and protects Hodgkin and Reed-Sternberg cells from apoptosis. (PMID:28432871)
• mirn 146a/b-5 and 425-3p and 24-3p may have roles in response to antidepressants and in regulating MAPK/Wnt-system genes (PMID:28530238)
• Elevated expression of hsa-miR-24 and hsa-miR-28 mark the first epigenetic changes observed between sporadic and MEN1-associated primary hyperparathyroidism (PMID:28597079)
• the results of the present study identified miR-24-2 as an oncogene associated with cell proliferation, migration, invasion and apoptosis in RCC, which indicated that miR-24-2 may be involved in RCC tumorigenesis and development. (PMID:28990105)
• Attenuation of miR-24-3p expression is associated with the development of severe gastric mucosa lesions. H. pylori may play a role in miR-24-3p regulation in the early stage of gastric mucosa lesions (PMID:29050151)
• Data found that both miR-7a and miR-24-3p had a significantly higher copy number in non-malignant lung tissues (NMLTs) samples compared to lung adenocarcinoma (AC) tissues and that they both modulate the SOX18 transcript in AC cells. (PMID:29115529)
• Serum levels of miR-24-2 in CRC patients were significantly higher than healthy subjects (p< 0.05). In addition, the expression level of the miR-24-2 was decreased with the progression of CRC and reached the lowest level in CRC V. (PMID:29171985)
• miR-24 accelerates atherogenesis by repressing SR-BI-mediated selective lipid uptake from HDL-C. (PMID:29407889)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir24-3	ENSDARG00000080599

Paralogs (2): MIR3074 (ENSG00000207617), MIR24-1 (ENSG00000284459)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.