MIR2467

Summary

MIR2467 (microRNA 2467, HGNC:41881) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616360 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41881
Approved symbol	MIR2467
Name	microRNA 2467
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2467
Ensembl gene	ENSG00000264292
Ensembl biotype	miRNA
Entrez	100616360
RNAcentral	URS000075BF5E — ncRNA, 81 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584559

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584559 — 1 exons

Exon	Start	End
ENSE00002731615	239351724	239351804

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 88.98.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	88.98	gold quality
adult mammalian kidney	UBERON:0000082	88.60	gold quality
blood	UBERON:0000178	81.23	gold quality
liver	UBERON:0002107	80.82	gold quality
prefrontal cortex	UBERON:0000451	80.38	gold quality
kidney	UBERON:0002113	77.44	gold quality
stomach	UBERON:0000945	77.41	gold quality
adrenal tissue	UBERON:0018303	76.50	gold quality
monocyte	CL:0000576	75.18	gold quality
muscle of leg	UBERON:0001383	74.35	gold quality
lymph node	UBERON:0000029	74.00	gold quality
gastrocnemius	UBERON:0001388	73.06	gold quality
calcaneal tendon	UBERON:0003701	72.46	gold quality
endometrium	UBERON:0001295	71.81	gold quality
sural nerve	UBERON:0015488	71.81	gold quality
heart	UBERON:0000948	70.14	gold quality
body of pancreas	UBERON:0001150	70.14	gold quality
body of stomach	UBERON:0001161	70.08	gold quality
heart left ventricle	UBERON:0002084	69.86	gold quality
lung	UBERON:0002048	69.79	gold quality
left adrenal gland cortex	UBERON:0035825	68.82	gold quality
left adrenal gland	UBERON:0001234	68.66	gold quality
right lobe of liver	UBERON:0001114	67.97	gold quality
colon	UBERON:0001155	67.87	gold quality
substantia nigra	UBERON:0002038	67.87	gold quality
intestine	UBERON:0000160	67.52	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.20	gold quality
tibial artery	UBERON:0007610	66.70	gold quality
urinary bladder	UBERON:0001255	66.63	gold quality
popliteal artery	UBERON:0002250	66.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR-2467-3p sequestration. (PMID:31549406)
• SNHG22 overexpression indicates poor prognosis and induces chemotherapy resistance via the miR-2467/Gal-1 signaling pathway in epithelial ovarian carcinoma. (PMID:31581131)
• MiR-2467 is a Potential Marker for Prediction of Gestational Diabetes Mellitus in Pregnancy. (PMID:33073943)
• Circ_0074027 contributes to non-small cell lung cancer progression through positively modulating RHOA via sequestering miR-2467-3p. (PMID:33687619)
• Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467. (PMID:34403779)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.