MIR2681

Summary

MIR2681 (microRNA 2681, HGNC:41532) is a microRNA gene on chromosome 13q33.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616110 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41532
Approved symbol	MIR2681
Name	microRNA 2681
Location	13q33.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2681
Ensembl gene	ENSG00000265164
Ensembl biotype	miRNA
Entrez	100616110
RNAcentral	URS0000759AE2 — ncRNA, 105 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581814

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581814 — 1 exons

Exon	Start	End
ENSE00002701246	101967642	101967746

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 90.93.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	90.93	gold quality
heart left ventricle	UBERON:0002084	88.24	gold quality
adrenal tissue	UBERON:0018303	86.03	gold quality
calcaneal tendon	UBERON:0003701	81.57	gold quality
endometrium	UBERON:0001295	76.70	gold quality
stomach	UBERON:0000945	75.29	gold quality
kidney	UBERON:0002113	73.17	gold quality
Ammon’s horn	UBERON:0001954	72.59	gold quality
gastrocnemius	UBERON:0001388	72.06	gold quality
left coronary artery	UBERON:0001626	70.78	gold quality
transverse colon	UBERON:0001157	70.62	gold quality
heart	UBERON:0000948	70.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.42	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.06	gold quality
body of pancreas	UBERON:0001150	69.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.52	gold quality
caudate nucleus	UBERON:0001873	69.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.32	gold quality
prostate gland	UBERON:0002367	69.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.11	gold quality
right atrium auricular region	UBERON:0006631	68.58	gold quality
omental fat pad	UBERON:0010414	68.44	gold quality
cerebellar hemisphere	UBERON:0002245	68.28	gold quality
body of stomach	UBERON:0001161	67.97	gold quality
colon	UBERON:0001155	67.82	gold quality
tibial artery	UBERON:0007610	67.44	gold quality
intestine	UBERON:0000160	67.37	gold quality
right frontal lobe	UBERON:0002810	67.30	gold quality
adult mammalian kidney	UBERON:0000082	67.13	gold quality
liver	UBERON:0002107	67.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.