MIR2682

Summary

MIR2682 (microRNA 2682, HGNC:41688) is a microRNA gene on chromosome 1p21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616452 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41688
Approved symbol	MIR2682
Name	microRNA 2682
Location	1p21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2682
Ensembl gene	ENSG00000284247
Ensembl biotype	miRNA
Entrez	100616452
RNAcentral	URS000075F0A0 — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580305

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580305 — 1 exons

Exon	Start	End
ENSE00002727654	98045242	98045351

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 73.89.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	73.89	gold quality
putamen	UBERON:0001874	66.11	gold quality
tibial nerve	UBERON:0001323	66.03	gold quality
tibial artery	UBERON:0007610	65.68	gold quality
left adrenal gland cortex	UBERON:0035825	65.35	gold quality
hypothalamus	UBERON:0001898	64.42	gold quality
nucleus accumbens	UBERON:0001882	63.09	gold quality
caudate nucleus	UBERON:0001873	60.66	gold quality
pituitary gland	UBERON:0000007	58.87	gold quality
substantia nigra	UBERON:0002038	57.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	57.79	gold quality
right frontal lobe	UBERON:0002810	56.48	gold quality
adenohypophysis	UBERON:0002196	50.20	gold quality
anterior cingulate cortex	UBERON:0009835	43.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Rare noncoding risk variants are associated with Schizophrenia (SZ) and bipolar (BP) at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression. (PMID:25434007)
• ELK1/lncRNA-SNHG7/miR-2682-5p feedback loop enhances bladder cancer cell growth. (PMID:32898531)
• SNHG3/miR-2682-5p/HOXB8 promotes cell proliferation and migration in oral squamous cell carcinoma. (PMID:32989886)
• MIR137/MIR2682 locus is associated with perineural invasiveness in head and neck cancer. (PMID:33740841)
• miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer. (PMID:35733138)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.