MIR26A2

Summary

MIR26A2 (microRNA 26a-2, HGNC:31611) is a microRNA gene on chromosome 12q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407016 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31611
Approved symbol	MIR26A2
Name	microRNA 26a-2
Location	12q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-26a-2
Ensembl gene	ENSG00000207789
Ensembl biotype	miRNA
OMIM	613057
Entrez	407016
RNAcentral	URS000075C1BF — miRNA, 84 nt, 48 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385054

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385054 — 1 exons

Exon	Start	End
ENSE00001500060	57824609	57824692

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 85.81.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	85.81	gold quality
adrenal tissue	UBERON:0018303	81.26	gold quality
bone marrow	UBERON:0002371	78.49	gold quality
calcaneal tendon	UBERON:0003701	78.47	gold quality
blood	UBERON:0000178	78.34	gold quality
monocyte	CL:0000576	77.52	gold quality
placenta	UBERON:0001987	77.04	gold quality
granulocyte	CL:0000094	76.67	gold quality
muscle of leg	UBERON:0001383	76.43	gold quality
gastrocnemius	UBERON:0001388	75.23	gold quality
mucosa of stomach	UBERON:0001199	74.76	gold quality
right lung	UBERON:0002167	74.60	gold quality
lymph node	UBERON:0000029	74.58	gold quality
islet of Langerhans	UBERON:0000006	74.31	gold quality
smooth muscle tissue	UBERON:0001135	74.03	gold quality
right coronary artery	UBERON:0001625	73.17	gold quality
heart left ventricle	UBERON:0002084	72.46	gold quality
liver	UBERON:0002107	72.32	gold quality
heart	UBERON:0000948	72.26	gold quality
right atrium auricular region	UBERON:0006631	72.05	gold quality
stomach	UBERON:0000945	71.51	gold quality
endometrium	UBERON:0001295	71.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.15	gold quality
tonsil	UBERON:0002372	70.91	gold quality
body of pancreas	UBERON:0001150	70.77	gold quality
body of stomach	UBERON:0001161	70.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.70	gold quality
tibial artery	UBERON:0007610	70.56	gold quality
popliteal artery	UBERON:0002250	70.52	gold quality
thoracic aorta	UBERON:0001515	70.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-26a and -26b were identified as key regulators of human white and brite adipocyte differentiation. (PMID:24375761)
• MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX. (PMID:24935220)
• The data validates p300 as a target of miR-26a, and demonstrates a mechanism by which M. tuberculosis can limit macrophage responses to IFN-gamma by altering host miRNA expression. (PMID:25252958)
• downregulation of miR-26a is involved in the progression of diabetic nephropathy both in humans and in mice through enhanced TGF-beta/CTGF signalling (PMID:26063197)
• Results suggest that microRNA miR-26a in serum might be a potential and useful noninvasive biomarker for the early detection of cholangiocarcinoma. (PMID:26087181)
• p53 gain-of-function mutations accelerate endometrial carcinoma progression and metastasis by interfering with Drosha and p68 binding and pri-miR-26a-1 processing, resulting in reduced miR-26a expression and EZH2 overexpression. (PMID:26587974)
• Data indicate that microRNA miR-26a regulated epithelial-mesenchymal transition (EMT) by targeting enhancer of zeste homolog 2 (EZH2). (PMID:26733151)
• miR-26 dampens IL-6 expression by down-regulating the TNF-alpha/NF-kappaB signalling axis through silencing two NF-kappaB signalling factors, HMGA1 and MALT1, and not by directly targeting IL-6 mRNA. (PMID:27025651)
• Our findings demonstrate for the first time that miR-26a/b can promote apoptosis and sensitize Hepatocellular carcinoma (HCC) to chemotherapy via suppressing the expression of autophagy initiator ULK1, and provide the reduction of miR-26a/b in HCC as a novel mechanism of tumor chemoresistance. (PMID:28079894)
• lncRNA UCA1 act as an endogenous sponge of miR-26a and downregulates miR-26a expression levels which regulates the migration and proliferation of vascular smooth muscle cells (PMID:29908280)
• TUG1 negatively regulates the expression of miR-26a in prostate cancer. (PMID:29967294)
• These findings revealed that a feedback loop between miR-26a and E2F7 may promote Tamoxifen resistance in estrogen receptor -positive breast cancer. (PMID:30066905)
• Study found that, in bladder cancer (BC) tissues, the levels of miR26a and miR26b were lower than in paired normal tissues. Further data indicated that miR26a and miR26b inhibited cell proliferation in BC cell lines. (PMID:30272373)
• miR-26a may reduce the expression level of SMAD1, affect the expression of epithelial-mesenchymal transition (EMT)-related proteins, inhibit the EMT function of Tu686 cells of squamous cell carcinoma of head and neck, and inhibit the invasion of them. (PMID:30657563)
• Data suggested that ANXA1 negatively regulated miR-26a expression in non-small cell lung cancer (NSCLC). In the other hand, miR-26a negatively regulated NF-kappaB activation in NSCLC. (PMID:30756482)
• downregulation of miR-26a-5p plays essential roles in breast cancer by mediating RNF6/ERalpha/Bcl-xL axis. (PMID:31063232)
• TGF-beta2 induces MALAT1 overexpression, which in turn MALAT1 acts as a Competing Endogenous RNA targeting Smad4 by binding miR-26a (PMID:31143769)
• Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3K/AKT pathway. (PMID:31210329)
• exosomal miR-26a derived from prostate carcinoma cells had a suppressive effect on the metastasis and tumor growth of prostate carcinoma. (PMID:31229922)
• An integrated approach allowed to identify miR-26a-5p as the most stable reference gene and miR-212-3p as the worst one. (PMID:31234552)
• Effects of miR-26a/miR-146a/miR-31 on airway inflammation of asthma mice and asthma children. (PMID:31298396)
• These results demonstrate the first evidence of the significant effect of miR-26a and miR-26b on sucrose-isomaltase expression and activity. (PMID:31493868)
• MicroRNA-26a suppresses the malignant biological behaviors of papillary thyroid carcinoma by targeting ROCK1 and regulating PI3K/AKT signaling pathway. (PMID:31696481)
• Study demonstrates that TCF12 is a direct target of miR26a, and upregulation of miR26a resulted in TCF12 inhibition in epithelial ovarian cancer (OC) cells. Furthermore, the proliferation, migration and invasion were inhibited and apoptosis was induced by miR26a upregulation in OC cells. These results indicated that miR26a may act as a tumor suppressor in OC, and TCF12 targeting by miR26a. (PMID:31789414)
• MicroRNA-26a/b have protective roles in oral lichen planus. (PMID:31907356)
• Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma. (PMID:32193289)
• Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a. (PMID:32265934)
• The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma. (PMID:32453410)
• LncRNA KCNQ1OT1 knockdown inhibits viability, migration and epithelial-mesenchymal transition in human lens epithelial cells via miR-26a-5p/ITGAV/TGF-beta/Smad3 axis. (PMID:32950535)
• MicroRNA-26a inhibits wound healing through decreased keratinocytes migration by regulating ITGA5 through PI3K/AKT signaling pathway. (PMID:32955094)
• MiR-26a-5p as a Reference to Normalize MicroRNA qRT-PCR Levels in Plasma Exosomes of Pediatric Hematological Malignancies. (PMID:33429910)
• Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients: An observational study. (PMID:33761638)
• Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy. (PMID:33931763)
• MiR-26a regulates the expression of serum IGF-1 in patients with osteoporosis and its effect on proliferation and apoptosis of mouse chondrocytes. (PMID:34059575)
• Mechanism of bone marrow mesenchymal stem cells secreting miR-26a exosomes affecting high glucose-induced skin fibroblasts function by regulating TLR4/NF-kappaB signaling. (PMID:34185112)
• Runx1/miR-26a/Jagged1 signaling axis controls osteoclastogenesis and alleviates orthodontically induced inflammatory root resorption. (PMID:34438336)
• miR-26a-5p suppresses nasopharyngeal carcinoma progression by inhibiting PTGS2 expression. (PMID:35073820)
• Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer. (PMID:35094634)
• MiR-26a-5p as a useful therapeutic target for upper tract urothelial carcinoma by regulating WNT5A/beta-catenin signaling. (PMID:35484165)
• MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell. (PMID:35948893)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-26b	ENSDARG00000080579
danio_rerio	dre-mir-26a-1	ENSDARG00000080591
mus_musculus	Mir26a-2	ENSMUSG00000065430
rattus_norvegicus	Mir26a-2	ENSRNOG00000047216

Paralogs (2): MIR26A1 (ENSG00000199075), MIR26B (ENSG00000199121)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.