MIR27A

Summary

MIR27A (microRNA 27a, HGNC:31613) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407018 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31613
Approved symbol	MIR27A
Name	microRNA 27a
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-27a
Ensembl gene	ENSG00000207808
Ensembl biotype	miRNA
OMIM	612153
Entrez	407018
RNAcentral	URS0000233054 — miRNA, 78 nt, 23 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385073

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385073 — 1 exons

Exon	Start	End
ENSE00001500079	13836440	13836517

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 90.69.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal glomerulus	UBERON:0000074	90.69	gold quality
liver	UBERON:0002107	83.74	gold quality
placenta	UBERON:0001987	77.41	gold quality
thyroid gland	UBERON:0002046	73.66	gold quality
muscle of leg	UBERON:0001383	72.42	gold quality
blood	UBERON:0000178	69.23	gold quality
tibial artery	UBERON:0007610	69.04	gold quality
gastrocnemius	UBERON:0001388	68.63	gold quality
lymph node	UBERON:0000029	66.70	gold quality
ovary	UBERON:0000992	66.55	gold quality
left ovary	UBERON:0002119	66.55	gold quality
cerebral cortex	UBERON:0000956	65.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.55	gold quality
testis	UBERON:0000473	64.13	gold quality
spleen	UBERON:0002106	63.57	gold quality
Ammon’s horn	UBERON:0001954	62.27	gold quality
epididymis	UBERON:0001301	62.05	gold quality
omental fat pad	UBERON:0010414	61.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.44	gold quality
left adrenal gland cortex	UBERON:0035825	59.09	gold quality
putamen	UBERON:0001874	58.85	gold quality
islet of Langerhans	UBERON:0000006	56.73	gold quality
caudate nucleus	UBERON:0001873	56.18	gold quality
tibial nerve	UBERON:0001323	53.05	gold quality
right atrium auricular region	UBERON:0006631	52.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.44	gold quality
heart	UBERON:0000948	52.17	gold quality
heart left ventricle	UBERON:0002084	51.89	gold quality
uterus	UBERON:0000995	50.59	gold quality
endocervix	UBERON:0000458	50.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA1, RUNX1, SP1, SP3, SP4

Literature-anchored findings (GeneRIF, showing 40)

• The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects. (PMID:17546506)
• MicroRNAs miR-27a and miR-451 are involved in activating the expression of P-glycoprotein, the MDR1 gene product that confers cancer cell resistance to a broad range of chemotherapeutics. (PMID:18619946)
• MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin (PMID:18789835)
• miR-27a plays a regulatory role in megakaryocytic differentiation by attenuating Runx1 expression, during megakaryopoiesis, Runx1 and miR-27a are engaged in a feedback loop involving positive regulation of miR-27a expression by Runx1. (PMID:19114653)
• miR-23a, 27a, and 24-2 upregulation induces caspase-dependent and -independent apoptosis in human embryonic kidney cells (PMID:19513126)
• Suppression of miR-27a, miR-96, and miR-182 resulted in an increase in FOXO1 expression. (PMID:19574223)
• The [G] allele of rs895819, located in the terminal loop of pre-miR-27a oncogene, is associated with reduced familial breast cancer risk. (PMID:19921425)
• Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. (PMID:19948051)
• MiR-27a might play important roles in multidrug resistance of esophageal cancer. (PMID:19960259)
• Study show that miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10, thereby enhancing expression of ERalpha. (PMID:20382698)
• findings demonstrate that HSUR 1(Herpesvirus saimiri U-rich RNA)directs degradation of mature miR-27 in a sequence-specific & binding-dependent manner (PMID:20558719)
• The deregulation of miR-27a may be involved in the development of drug resistance, regulating the expression of MDR1/P-gp, at least in part, by targeting HIPK2 in ovarian cancer cells. (PMID:20624637)
• Data indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant, biological behavior of pancreatic cancer cells. (PMID:20638779)
• The expression of miR-27a is upregulated in A2780/Taxol cells, which may regulate MDR1 and P-gp expression by targeting HIPK2. (PMID:20646448)
• a common polymorphism (rs895819) in hsa-mir-27a, by modulating miR-27a and ZBTB10 levels, acted as an important factor of the gastric cancer susceptibility. (PMID:20666778)
• This study suggests miR-27 is an important mediator of osteoblast differentiation, thus offering a new target for the development of preventive or therapeutic agents against osteogenic disorders. (PMID:20708603)
• Study show thatb miRNAs of miR-23a27a24-2 cluster in relation to various health and diseased conditions and highlight the cooperative effects of the miRNAs of this cluster. (PMID:20815877)
• Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen (PMID:21460851)
• miR-27a was identified as a key regulator of p44 mRNA. Moreover, miR-27a was shown to destabilize the p44 subunit of the TFIIH complex during the G2-M phase, thereby modulating the transcriptional shutdown observed during this transition. (PMID:21558443)
• Down-regulation of miR-27a could significantly decrease the expression of P-glycoprotein and the transcriptional activity of cyclin D1, and up-regulate the expression of p21. (PMID:21569481)
• Taken together, this work underlines the role of ER stress in miR-23a27a24-2 cluster mediated apoptosis in HEK293T cells. (PMID:21593605)
• Data demonstrate that attenuation of FBW7 by miR-27a overexpression leads to improper cell cycle progression and DNA replication stress, consistent with dysregulation of cyclin E expression. (PMID:21597324)
• Human microRNA (miR)-27a* is a negative regulator of NK-cell cytotoxicity by silencing Prf1 and GzmB expression. (PMID:21960590)
• miR-27 has a role in regulating metastasis of gastric cancer. (PMID:22018270)
• Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3’-untranslated region of SEMA6A. (PMID:22184411)
• The results suggest that the [G] allele of rs895819 in miR-27a is not associated with breast cancer risk in the Italian population. (PMID:22415478)
• Androgens regulate miR-27a expression both transcriptionally and post-transcriptionally. (PMID:22505583)
• The inhibition of miR-27a by the stable expression of anti-miRNA significantly suppresses the proliferation and invasiveness of U87 glioma cells. (PMID:22614734)
• Report lack of association between mir-27a SNPs and colorectal cancer risk in caucasian population. (PMID:22719192)
• Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer (PMID:22761427)
• miR-27a is overexpressed in human glioma (PMID:22895821)
• TGF-beta-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7. (PMID:23034448)
• Reduced miR-27a increases tumor sphere formation and colony formation in small cell lung cancer. (PMID:23117485)
• Our results suggest that the pre-miR-27a rs895819 polymorphism can predict renal cell cancer risk in a Chinese population (PMID:23118855)
• We showed that miR-24 and miR-27a were significantly downregulated in HCCs from cirrhotic liver tissues in comparison to those from non-cirrhotic liver tissues. (PMID:23229173)
• These data indicate that miR-27a contributes a tumor suppressor-like activity in acute leukemia cells via regulation of apoptosis (PMID:23236401)
• High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression (PMID:23240057)
• results indicate that the G/A polymorphism in miR-27a gene (rs11671784) decreases miR-27a expression, reduces gastric cancer risk and plays a role in gastric tumorigenesis (PMID:23246964)
• These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. (PMID:23254855)
• Collectively, these results indicated that stimulation of ovarian cancer cell VEGF, Cox2 and survivin expression by FSH involves the microRNA27a: ZBTB10-specificity protein pathway. (PMID:23254909)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir27a	ENSDARG00000082454
danio_rerio	mir27c	ENSDARG00000083181
mus_musculus	Mir27a	ENSMUSG00000065444

Paralogs (1): MIR27B (ENSG00000207864)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.