MIR2861

Summary

MIR2861 (microRNA 2861, HGNC:38221) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of target mRNAs. This microRNA may play a role in osteoblast differentiation and a mutation in this gene is associated with osteoporosis. Altered expression of this microRNA has been observed in human cancers, with reduced expression seen in cervical cancer, while expression in papillary thyroid carcinoma (PTC) is increased.

Source: NCBI Gene 100422910 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38221
Approved symbol	MIR2861
Name	microRNA 2861
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2861
Ensembl gene	ENSG00000284547
Ensembl biotype	miRNA
OMIM	613405
Entrez	100422910
RNAcentral	URS000075ADBF — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636310

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636310 — 1 exons

Exon	Start	End
ENSE00003798722	127785918	127786007

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 78.79.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	78.79	gold quality
placenta	UBERON:0001987	75.12	gold quality
blood	UBERON:0000178	72.62	gold quality
heart left ventricle	UBERON:0002084	71.58	gold quality
gastrocnemius	UBERON:0001388	70.07	gold quality
body of pancreas	UBERON:0001150	69.46	gold quality
body of stomach	UBERON:0001161	69.25	gold quality
right atrium auricular region	UBERON:0006631	68.59	gold quality
heart	UBERON:0000948	68.09	gold quality
right adrenal gland	UBERON:0001233	66.43	gold quality
small intestine	UBERON:0002108	64.88	gold quality
tibial artery	UBERON:0007610	63.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.72	gold quality
substantia nigra	UBERON:0002038	62.58	gold quality
colon	UBERON:0001155	62.55	gold quality
adult mammalian kidney	UBERON:0000082	62.23	gold quality
skin of leg	UBERON:0001511	61.40	gold quality
minor salivary gland	UBERON:0001830	61.30	gold quality
esophagus mucosa	UBERON:0002469	61.24	gold quality
body of uterus	UBERON:0009853	61.24	gold quality
skeletal muscle tissue	UBERON:0001134	60.93	gold quality
transverse colon	UBERON:0001157	60.92	gold quality
left coronary artery	UBERON:0001626	60.86	gold quality
upper lobe of left lung	UBERON:0008952	60.67	gold quality
Ammon’s horn	UBERON:0001954	60.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.60	gold quality
left adrenal gland	UBERON:0001234	60.55	gold quality
amygdala	UBERON:0001876	60.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• a homozygous mutation in pre-miR-2861 that blocked expression of miR-2861, targeting HDAC5, was shown to cause primary osteoporosis in 2 related adolescents (PMID:19920351)
• Investigated miRNA deregulation in papillary thyroid carcinoma, particularly with lymph node (LN) metastasis. Expression of either miR-2861 or miR-451 in the LN group was significantly greater than that in the NLN group. (PMID:23609190)
• we have established a serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) that could distinguish CC from CIN and healthy controls with high accuracy. (PMID:26656154)
• the overexpression of miR-2861 and RUNX2 in human Periodontal Ligament Stem Cells cultured in presence of 3D Endobon Xenograft granule scaffold under osteogenic and standard conditions was demonstrated (PMID:28078846)
• Further origin identification revealed that the expression levels of miR-122 in CECs and lymphocytes, miR-140-3p and -2861 in monocytes and CECs, miR-720 in monocytes, and miR-3149 in CECs were greatly up-regulated in the ACS patients compared with the non-ACS patients (PMID:28961259)
• miR-2861 expression was significantly higher in lung cancer stem cells (LCSCs) no matter compared to the differentiation cells or normal cells. HDAC5 expression was positively correlated with miR-2861 in LCSCs, and knockdown of miR-2861 decreased the expression of HDAC5, which implied that HDAC5 may be involved in the differentiation of LCSCs mediated by miR-2861. (PMID:29620443)
• Our study reveals that miR-2861 was lowly expressed in endometriotic tissues, and downregulation of miR-2861 may promote proliferation and inhibit apoptosis of ectopic endometrial cells in endometriosis via upregulation of STAT3 and MMP2. (PMID:30940310)
• SNHG14 induces osteogenic differentiation of human stromal (mesenchymal) stem cells in vitro by downregulating miR-2861. (PMID:32770994)
• LncRNA MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation. (PMID:33624428)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.