MIR2909

Summary

MIR2909 (microRNA 2909, HGNC:38372) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422969 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38372
Approved symbol	MIR2909
Name	microRNA 2909
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2909
Ensembl gene	ENSG00000276326
Ensembl biotype	miRNA
Entrez	100422969
RNAcentral	URS000075C656 — ncRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617113

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617113 — 1 exons

Exon	Start	End
ENSE00003748721	37033745	37033813

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 84.97.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	84.97	gold quality
calcaneal tendon	UBERON:0003701	83.81	gold quality
kidney	UBERON:0002113	82.72	gold quality
corpus callosum	UBERON:0002336	81.88	gold quality
liver	UBERON:0002107	79.44	gold quality
blood	UBERON:0000178	78.36	gold quality
muscle of leg	UBERON:0001383	77.87	gold quality
bone marrow	UBERON:0002371	77.71	gold quality
adrenal tissue	UBERON:0018303	76.86	gold quality
monocyte	CL:0000576	76.53	gold quality
left coronary artery	UBERON:0001626	75.58	gold quality
gastrocnemius	UBERON:0001388	73.94	gold quality
islet of Langerhans	UBERON:0000006	73.32	gold quality
stomach	UBERON:0000945	73.32	gold quality
heart	UBERON:0000948	71.20	gold quality
body of stomach	UBERON:0001161	69.96	gold quality
body of pancreas	UBERON:0001150	69.02	gold quality
tibial artery	UBERON:0007610	69.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.92	gold quality
Ammon’s horn	UBERON:0001954	68.29	gold quality
lung	UBERON:0002048	68.07	gold quality
right atrium auricular region	UBERON:0006631	67.89	gold quality
body of uterus	UBERON:0009853	67.73	gold quality
heart left ventricle	UBERON:0002084	67.27	gold quality
lower esophagus	UBERON:0013473	67.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.14	gold quality
colon	UBERON:0001155	66.84	gold quality
skin of leg	UBERON:0001511	66.82	gold quality
zone of skin	UBERON:0000014	66.74	gold quality
intestine	UBERON:0000160	66.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• results suggest that miR-2909 may modulate native immunity in general and help in providing protective immunity against viral infections in particular (PMID:22504889)
• propose that miR-2909 RNomics may be a step forward in understanding human CHD at the epigenomic level and can be exploited for designing new therapeutic strategies as well as diagnostic and prognostic markers for this disease in future (PMID:24634009)
• This study identified a novel miR-2909-KLF4 molecular axis able to differentiate between the pathogeneses of pediatric B- and T-cell ALLs, and which may represent a new diagnostic/prognostic marker. (PMID:25037230)
• MALT1 exerts its effect upon immune response through the initiation of cellular miR-2909 RNomics. (PMID:25500259)
• High glucose-induced human cellular immune response is governed by miR-2909. (PMID:25616369)
• In the face of high glucose threat, mitochondrial UCP2 gene expression is regulated by miR-2909 and AATF. (PMID:25976474)
• High miR-2909 expression is associated with Th1 immune response coupled with effector IgA class switching thereby tailoring their immune system to ensure increased risk to infections and chronic diseases. (PMID:26302178)
• miR-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta signalling via STAT1/SOCS3. (PMID:28622443)
• study shows that androgen receptor and miR-2909 drives the down-regulation of TGFBR2 by acting through positive feedback loop and thereby attenuating the inhibitory effects of TGFbeta signaling (PMID:28754634)
• Studied recruitment patterns of urinary-exosomal miR-2909 in bladder and prostate cancer and its relation to disease severity. (PMID:28764970)
• Post-transcriptional modification, especially 3’-end adenylation and uridylation of miR-2909, exerts opposing effects that may contribute to direct its sorting into exosomes secreted by cancer cells. (PMID:29468700)
• the role of miR-2909 in the regulation of mitochondrial function within human melanocytes, is reported. (PMID:30506863)
• Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway. (PMID:33039241)
• Prediction of recurrence of non-muscle invasive bladder cancer: The role of androgen receptor and miRNA-2909. (PMID:35430138)
• Integrative Expression, Survival Analysis and Cellular miR-2909 Molecular Interplay in MRN Complex Check Point Sensor Genes (MRN-CSG) Involved in Breast Cancer. (PMID:36220723)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.