MIR297

Summary

MIR297 (microRNA 297, HGNC:33691) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126354 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33691
Approved symbol	MIR297
Name	microRNA 297
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-297
Ensembl gene	ENSG00000215961
Ensembl biotype	miRNA
OMIM	615520
Entrez	100126354
RNAcentral	URS000075A3FD — miRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401142

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401142 — 1 exons

Exon	Start	End
ENSE00001546486	110860582	110860647

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 77.08.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	77.08	gold quality
gastrocnemius	UBERON:0001388	76.10	gold quality
monocyte	CL:0000576	72.65	gold quality
islet of Langerhans	UBERON:0000006	72.09	gold quality
intestine	UBERON:0000160	70.64	gold quality
body of stomach	UBERON:0001161	69.35	gold quality
transverse colon	UBERON:0001157	69.08	gold quality
ascending aorta	UBERON:0001496	68.95	gold quality
amygdala	UBERON:0001876	68.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.69	gold quality
zone of skin	UBERON:0000014	68.43	gold quality
putamen	UBERON:0001874	67.90	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.81	gold quality
skin of leg	UBERON:0001511	66.76	gold quality
tibial artery	UBERON:0007610	66.40	gold quality
thoracic mammary gland	UBERON:0005200	66.11	gold quality
tibial nerve	UBERON:0001323	65.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.45	gold quality
left coronary artery	UBERON:0001626	65.38	gold quality
omental fat pad	UBERON:0010414	65.34	gold quality
right frontal lobe	UBERON:0002810	65.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.10	gold quality
spleen	UBERON:0002106	64.55	gold quality
vagina	UBERON:0000996	64.37	gold quality
minor salivary gland	UBERON:0001830	64.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.62	gold quality
thyroid gland	UBERON:0002046	63.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.80	gold quality
prostate gland	UBERON:0002367	62.05	gold quality
left ovary	UBERON:0002119	61.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Data suggest that expression of MIRN297 is negatively correlated with MRP2 (multidrug resistance-associated protein 2) expression in colorectal carcinoma cells; response of colorectal adenocarcinoma cells to MIRN297 involves down-regulation of MRP2. (PMID:22676135)
• Loss of Mir-297 is associated with glioblastoma. (PMID:24158111)
• These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung. (PMID:27554041)
• The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer. (PMID:28091918)
• The miR-297 inhibited LPS-induced inflammatory response and apoptosis of HUVECs by regulating STAT3 signaling pathway. (PMID:30921508)
• MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8. (PMID:31945608)
• The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair. (PMID:31973814)
• Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3. (PMID:34559973)
• miR-297 inhibits expression of progesterone receptor and decidualization in eutopic endometria of endometriosis. (PMID:36572643)
• MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3. (PMID:37633911)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.