MIR29B2

Summary

MIR29B2 (microRNA 29b-2, HGNC:31620) is a microRNA gene on chromosome 1q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407025 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31620
Approved symbol	MIR29B2
Name	microRNA 29b-2
Location	1q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-29b-2
Ensembl gene	ENSG00000284203
Ensembl biotype	miRNA
OMIM	619035
Entrez	407025
RNAcentral	URS00001E96DA — miRNA, 81 nt, 49 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385055

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385055 — 1 exons

Exon	Start	End
ENSE00001500061	207802443	207802523

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 86.44.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	86.44	gold quality
monocyte	CL:0000576	75.86	gold quality
right lobe of liver	UBERON:0001114	66.02	gold quality
blood	UBERON:0000178	64.15	gold quality
gastrocnemius	UBERON:0001388	61.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.74	gold quality
substantia nigra	UBERON:0002038	59.72	gold quality
putamen	UBERON:0001874	59.43	gold quality
Ammon’s horn	UBERON:0001954	59.27	gold quality
anterior cingulate cortex	UBERON:0009835	59.11	gold quality
omental fat pad	UBERON:0010414	59.10	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	56.31	gold quality
tibial nerve	UBERON:0001323	56.23	gold quality
amygdala	UBERON:0001876	56.07	gold quality
cerebellar hemisphere	UBERON:0002245	54.36	gold quality
esophagus mucosa	UBERON:0002469	54.29	gold quality
ascending aorta	UBERON:0001496	52.76	gold quality
hypothalamus	UBERON:0001898	50.59	gold quality
skin of leg	UBERON:0001511	48.94	gold quality
skin of abdomen	UBERON:0001416	47.92	gold quality
left lobe of thyroid gland	UBERON:0001120	46.68	gold quality
thyroid gland	UBERON:0002046	45.89	gold quality
spleen	UBERON:0002106	44.08	silver quality
lower esophagus muscularis layer	UBERON:0035833	41.77	silver quality
thoracic mammary gland	UBERON:0005200	41.57	gold quality
small intestine Peyer’s patch	UBERON:0003454	39.98	silver quality
nucleus accumbens	UBERON:0001882	38.73	silver quality
left testis	UBERON:0004533	37.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• These findings identify miR-29b as a novel posttranscriptional regulator of PGRN expression, raising the possibility that miR-29b or other miRNAs might be targeted therapeutically to increase hPGRN levels in some frontotemporal dementia patients. (PMID:20479936)
• MicroRNA-29b was profoundly increased in biopsies of human thoracic aneurysms. (PMID:21903938)
• Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia. (PMID:22096249)
• MiR-29 expression is suppressed by progestins in breast cancer cells. (PMID:22751119)
• Results suggest that miR-29b negatively regulates DNA methyltransferase 1 (DNMT1) expression by targeting sp1 in T cells. Overexpression of miR-29b contributes to reduction of DNMT1 levels and DNA hypomethylation in systemic lupus erythematosus. (PMID:23142053)
• Sp1 is a negative regulator of miR-29b expression in multiple myeloma cells. (PMID:23190608)
• miR-29b show lower expression levels during osteoblast differentiation of bone marrow stromal cells from Osteogenesis Imperfecta patients (PMID:24767406)
• Results show that miR- 29b negatively regulates Wnt signaling in human colorectal cancer cells and targets BCL9L, TCF7L2, and SNAI1. (PMID:24913975)
• Results show that aberrant miR-29 expression may account for reduced NMI expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth. (PMID:25174825)
• MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. (PMID:25277410)
• a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis (PMID:25283360)
• miR-29b may play an important role in osteosarcoma progression by negatively regulating the expression of VEGF, suppressing proliferation and inducing apoptosis. (PMID:25337211)
• miR-29b prevents liver fibrogenesis by inhibiting HSC activation and inducing HSC apoptosis through inhibiting PI3K/AKT pathway (PMID:25356754)
• A positive feedback loop between IRF1 and miR-29b may contribute to the sensitivity of colorectal cancer cells to IFN-gamma by repressing IGF1. (PMID:25592039)
• YB-1 binds extensively to the terminal loop region of pri-/pre-miR-29b-2 and regulates the biogenesis of miR-29b-2 by blocking the recruitment of microprocessor and Dicer to its precursors. (PMID:26240386)
• Global 5-hmC modification regulated by miR-29b represses FOXA1 activity in prostate cancer. (PMID:26404510)
• Suggest that miR-29b acts as an oncomiR, promoting proliferation and invasion ability through KIF1B suppression in renal cell carcinoma. (PMID:26823729)
• Results show that miR-29b directly targets HDAC4 in multiple myeloma cells and its reduced mRNA expression inversely correlates with HDAC4 levels in multiple myeloma samples. (PMID:27196750)
• a complexity in cancer for miR-29b, which can act as either an oncogene or tumor suppressor gene depending on signaling context (PMID:27199349)
• miRNA-29 family is consistently down-regulated in leiomyoma compared to matched myometrial tissue. This down-regulation contributes to the increased collagen seen in leiomyomas versus myometrium. (PMID:27233758)
• The miR-29b/KDM2A axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis. (PMID:27497248)
• identification of a novel role for miR-29b-3p in regulating melanoma invasiveness (PMID:27852308)
• induction of MCL-1 by IL-6/IL-8 may surmount any direct down-regulation by miR-29b via its 3’-UTR. (PMID:28190086)
• Findings indicated that the miR-29b/SIRT1 axis has a protective effect against H2O2-induced damage of cell viability and oxidative stress and may provide novel options for miR-29b-based therapeutic approaches for EOC treatment. (PMID:29050034)
• miR-29b-2-5p improves prognosis in pancreatic ductal adenocarcinoma (PDAC) by targeting Cbl-b to promote p53 expression. (PMID:29940895)
• we demonstrate that the transcription factor aryl hydrocarbon receptor (AHR) directly regulates miR-29b expression (PMID:30158248)
• overexpression of miR-29 mitigated the formation of mutant alphaB-crystallin (R120G) protein aggregates. I (PMID:30513336)
• NEAT1 promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells by regulating miR-29b-3p/BMP1 axis. (PMID:30638953)
• MiR-29b directly regulates matrix metallopeptidase 9 that implicated in the tumorigenesis of osteosarcoma. Restoration of miR-29b in MG-63 cells suppresses cells’ proliferation and induces apoptosis. (PMID:30840264)
• Study provides evidence that low expression of miR-29b and miR-34a represent indicators for the prognosis of both Uygur and Han patients with chronic lymphocytic leukemia. (PMID:31425738)
• TNF-alpha-elicited miR-29b potentiates resistance to apoptosis in peripheral blood monocytes from rheumatoid arthritis patients via inhibition of HBP1 signaling. (PMID:31473844)
• Expression of miR-29 and STAT3 in osteosarcoma and its effect on proliferation regulation of osteosarcoma cells. (PMID:31539114)
• Novel miR-29b target regulation patterns are revealed in two different cell lines. (PMID:31767948)
• The down-regulated expressions of serum miR-24 and miR-29b are correlated with the severity degree of neurological impairment and neural function prognosis of elderly acute ischemic stroke patients (PMID:32148236)
• Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis. (PMID:32235655)
• miR29 mediates exerciseinduced skeletal muscle angiogenesis by targeting VEGFA, COL4A1 and COL4A2 via the PI3K/Akt signaling pathway. (PMID:32467996)
• level of miR-29b was positively associated with TGF-beta1, C-reactive protein, and urinary albumin/creatinine ratio, while negatively related to glomerular filtration rate (PMID:32631160)
• Association of the serum microRNA-29 family with cognitive impairment in Parkinson’s disease. (PMID:32649312)
• Serum miR-29a/b expression in gestational diabetes mellitus and its influence on prognosis evaluation. (PMID:32993411)
• miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors. (PMID:33171493)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-29b-1	ENSDARG00000080152
mus_musculus	Mir29b-2	ENSMUSG00000065412
rattus_norvegicus	Mir29b-3	ENSRNOG00000035637

Paralogs (3): MIR29B1 (ENSG00000283797), MIR29A (ENSG00000284032), MIR29C (ENSG00000284214)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.