MIR302C

Summary

MIR302C (microRNA 302c, HGNC:31764) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442895 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31764
Approved symbol	MIR302C
Name	microRNA 302c
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-302c
Ensembl gene	ENSG00000199102
Ensembl biotype	miRNA
OMIM	614598
Entrez	442895
RNAcentral	URS000071C6FC — miRNA, 68 nt, 31 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362232 — 1 exons

Exon	Start	End
ENSE00001436995	112648363	112648430

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 81.40.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.40	gold quality
blood	UBERON:0000178	80.29	gold quality
bone marrow	UBERON:0002371	79.99	gold quality
lymph node	UBERON:0000029	78.97	gold quality
endometrium	UBERON:0001295	78.02	gold quality
calcaneal tendon	UBERON:0003701	77.21	gold quality
placenta	UBERON:0001987	76.39	gold quality
monocyte	CL:0000576	76.08	gold quality
muscle of leg	UBERON:0001383	74.48	gold quality
stomach	UBERON:0000945	73.40	gold quality
smooth muscle tissue	UBERON:0001135	73.12	gold quality
liver	UBERON:0002107	73.07	gold quality
gastrocnemius	UBERON:0001388	72.80	gold quality
kidney	UBERON:0002113	72.33	gold quality
islet of Langerhans	UBERON:0000006	71.76	gold quality
heart	UBERON:0000948	71.33	gold quality
body of stomach	UBERON:0001161	71.14	gold quality
tonsil	UBERON:0002372	70.97	gold quality
endocervix	UBERON:0000458	70.86	gold quality
heart left ventricle	UBERON:0002084	70.54	gold quality
right lobe of liver	UBERON:0001114	69.81	gold quality
adrenal gland	UBERON:0002369	69.70	gold quality
ectocervix	UBERON:0012249	69.51	gold quality
body of pancreas	UBERON:0001150	69.32	gold quality
rectum	UBERON:0001052	69.29	gold quality
lung	UBERON:0002048	69.11	gold quality
right atrium auricular region	UBERON:0006631	69.07	gold quality
right adrenal gland	UBERON:0001233	69.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.87	gold quality
right adrenal gland cortex	UBERON:0035827	68.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-18a, miR-18b, miR-193b, miR-206 and miR-302c, were confirmed to directly target ERalpha in 3’-untranslated region reporter assays. (PMID:19684618)
• Data show that the hESC-enriched miRNA family miR-302 (miR-302a, miR-302b, miR-302c, and miR-302d) directly contributes to regulation of p21 expression in hESCs and, thus, demonstrate a novel function for miR-302s in hESCS. (PMID:22511267)
• Endothelial cell-specific miR-302c suppresses tumor growth in hepatocellular carcinoma through MTDH-mediated inhibition of endothelial-mesenchymal transition. (PMID:25027009)
• MiR-302c regulates proliferation and protects against oxidant-induced cell death mediated by the target genes CDKN1A and CCL5. (PMID:25144720)
• miR-302c-3p play a pivotal role in the progression of glioma by targeting MTDH and is a potential inhibitor in glioma treatment. (PMID:26176806)
• RACK1 modulated the IL8 expression and tumor invasion through miRNA-302c. (PMID:26199092)
• we provided evidences to imply that miR-302c-3p downregulation in human RCC cells causes Gab2 over-expression, Akt hyper-activation and cell proliferation. (PMID:28412750)
• Study showed that miR-302 microRNA cluster genes are involved in in vitro dedifferentiation of human pancreatic islet cells and inhibits the expression of multiple genes involved in the maintenance of beta-cell mature phenotype. (PMID:29649109)
• Proliferation and apoptosis assays demonstrated that miR-181a/135a/302c function as tumor suppressors via repressing PLAG1/IGF2 signaling. (PMID:29735329)
• These data indicate that miR-302c represses epithelial-mesenchymal transition and colorectal cancer metastasis possibly by targeting TFAP4. (PMID:29906744)
• LINC00460 promotes LC progression by competitively binding miR-302c-5p and regulating FOXA1 signal pathway. (PMID:30359741)
• Association and in silico investigations of miR-302c insertion/deletion variant as a novel biomarker with susceptibility to gastric cancer. (PMID:31219213)
• miRNA-302s may act as oncogenes in human testicular germ cell tumours. (PMID:31235829)
• Downregulation of miR-302b is associated with poor prognosis and tumor progression of breast cancer. (PMID:31721061)
• CircFAT1 Suppresses Colorectal Cancer Development Through Regulating miR-520b/UHRF1 Axis or miR-302c-3p/UHRF1 Axis. (PMID:32379550)
• Inhibition of MicroRNA-302c on Stemness of Colon Cancer Stem Cells via the CARF/Wnt/beta-Catenin Axis. (PMID:32617772)
• miR302c3p and miR520a3p suppress the proliferation of cervical carcinoma cells by targeting CXCL8. (PMID:33760117)
• MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1. (PMID:36539366)
• Human Embryonic Stem-Cell-Derived Exosomes Repress NLRP3 Inflammasome to Alleviate Pyroptosis in Nucleus Pulposus Cells by Transmitting miR-302c. (PMID:37108824)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir302c	ENSMUSG00000065482

Paralogs (3): MIR302D (ENSG00000199145), MIR302A (ENSG00000207927), MIR302B (ENSG00000284463)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.