MIR302D

Summary

MIR302D (microRNA 302d, HGNC:31765) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442896 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31765
Approved symbol	MIR302D
Name	microRNA 302d
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-302d
Ensembl gene	ENSG00000199145
Ensembl biotype	miRNA
OMIM	614599
Entrez	442896
RNAcentral	URS00006BBE85 — miRNA, 68 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362275

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362275 — 1 exons

Exon	Start	End
ENSE00001437038	112648004	112648071

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 90.81.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	90.81	gold quality
adrenal tissue	UBERON:0018303	89.76	gold quality
lymph node	UBERON:0000029	88.51	gold quality
placenta	UBERON:0001987	85.23	gold quality
bone marrow	UBERON:0002371	81.77	gold quality
calcaneal tendon	UBERON:0003701	80.57	gold quality
blood	UBERON:0000178	79.51	gold quality
muscle of leg	UBERON:0001383	77.57	gold quality
rectum	UBERON:0001052	76.08	gold quality
monocyte	CL:0000576	75.32	gold quality
endometrium	UBERON:0001295	74.49	gold quality
prefrontal cortex	UBERON:0000451	73.62	gold quality
gastrocnemius	UBERON:0001388	73.61	gold quality
kidney	UBERON:0002113	72.49	gold quality
stomach	UBERON:0000945	72.00	gold quality
tonsil	UBERON:0002372	71.41	gold quality
adult mammalian kidney	UBERON:0000082	70.74	gold quality
heart	UBERON:0000948	70.72	gold quality
left uterine tube	UBERON:0001303	70.42	gold quality
heart left ventricle	UBERON:0002084	70.19	gold quality
body of pancreas	UBERON:0001150	69.96	gold quality
body of stomach	UBERON:0001161	69.25	gold quality
urinary bladder	UBERON:0001255	69.25	gold quality
right adrenal gland	UBERON:0001233	68.81	gold quality
liver	UBERON:0002107	68.58	gold quality
substantia nigra	UBERON:0002038	68.00	gold quality
right lobe of liver	UBERON:0001114	67.78	gold quality
right atrium auricular region	UBERON:0006631	67.60	gold quality
intestine	UBERON:0000160	67.51	gold quality
caudate nucleus	UBERON:0001873	67.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• MiR-302d regulates proliferation and protects against oxidant-induced cell death mediated by the target genes CDKN1A and CCL5. (PMID:25144720)
• Expression of miR-302D was significantly high in germ cell tumors than in clear cell carcinomas of the ovary. (PMID:25238166)
• these findings identify miR-302d as a key regulator of type I IFN driven gene expression via its ability to target IRF9 and regulate ISG expression, underscoring the importance of non-coding RNA in regulating the IFN pathway in SLE. (PMID:28318807)
• Study showed that miR-302 microRNA cluster genes are involved in in vitro dedifferentiation of human pancreatic islet cells and inhibits the expression of multiple genes involved in the maintenance of beta-cell mature phenotype. (PMID:29649109)
• MiR-302d-3p promotes RPE dedifferentiation, migration, proliferation and cell-cycle progression, inhibits RPE phagocytosis, and induces abnormal EC behavior by targeting p21(Waf1/Cip1). (PMID:29670082)
• MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance. (PMID:29889802)
• Data provide the first evidence that E2F7 is a direct target of miRNA-302a/d and miRNA-302a/d inhibits the stemness of LCSCs and proliferation of HCC cells by targeting the E2F7/AKT/beta-catenin/CCND1 signaling pathway. (PMID:30326936)
• RELA promotes hypoxia-induced angiogenesis in human umbilical vascular endothelial cells via LINC01693/miR-302d/CXCL12 axis. (PMID:30937967)
• MicroRNA-302d promotes the proliferation of human pluripotent stem cell-derived cardiomyocytes by inhibiting LATS2 in the Hippo signaling pathway. (PMID:31239293)
• we reported upregulated miR-302d-3p and decreased ULK1 mRNA expression levels in the cartilaginous tissue of OA patients. (PMID:31524222)
• miR302d3p regulates the viability, migration and apoptosis of breast cancer cells through regulating the TMBIM6mediated ERK signaling pathway. (PMID:34651659)
• MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells. (PMID:36441751)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir302d	ENSMUSG00000065447

Paralogs (3): MIR302C (ENSG00000199102), MIR302A (ENSG00000207927), MIR302B (ENSG00000284463)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.