MIR302E

Summary

MIR302E (microRNA 302e, HGNC:35348) is a microRNA gene on chromosome 11p15.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313774 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35348
Approved symbol	MIR302E
Name	microRNA 302e
Location	11p15.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-302e
Ensembl gene	ENSG00000221703
Ensembl biotype	miRNA
Entrez	100313774
RNAcentral	URS000075B201 — miRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408776

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408776 — 1 exons

Exon	Start	End
ENSE00001565411	7234766	7234837

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 78.04.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	78.04	gold quality
kidney	UBERON:0002113	75.37	gold quality
intestine	UBERON:0000160	70.26	gold quality
transverse colon	UBERON:0001157	65.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.82	gold quality
minor salivary gland	UBERON:0001830	59.13	gold quality
left testis	UBERON:0004533	44.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Ectopic miR-302e remarkably suppressed the luciferase activity and expression of RelA, whereas down-regulation of miR-302e increased RelA luciferase activity and expression (PMID:29748238)
• The results of the present study indicated that sevoflurane exerts its neurotoxic effect by regulating the hsamiR302e/OXR1 axis. Therefore, the manipulation of the hsamiR302e/OXR1 pathway will be useful for preventing sevofluraneinduced neurotoxicity. (PMID:30221705)
• The inhibiting effects of FGD5-AS1 knockdown on colorectal cancer (CRC) cell proliferation, migration, and invasion, and the promoting effects on CRC cell apoptosis could be revived by miR-302e suppression or CDCA7 upregulation. (PMID:31332696)
• CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA. (PMID:31639291)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.