MIR3065

Summary

MIR3065 (microRNA 3065, HGNC:38234) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422915 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38234
Approved symbol	MIR3065
Name	microRNA 3065
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3065
Ensembl gene	ENSG00000211563
Ensembl biotype	miRNA
Entrez	100422915
RNAcentral	URS000075E912 — miRNA, 79 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390137

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390137 — 1 exons

Exon	Start	End
ENSE00001507564	81125877	81125955

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 98.81.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.81	gold quality
prefrontal cortex	UBERON:0000451	80.71	gold quality
blood	UBERON:0000178	79.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.31	gold quality
endometrium	UBERON:0001295	76.18	gold quality
adrenal tissue	UBERON:0018303	74.64	gold quality
right lobe of liver	UBERON:0001114	74.60	gold quality
monocyte	CL:0000576	73.97	gold quality
gastrocnemius	UBERON:0001388	73.81	gold quality
tibial nerve	UBERON:0001323	71.94	gold quality
right adrenal gland	UBERON:0001233	71.78	gold quality
body of stomach	UBERON:0001161	71.65	gold quality
stomach	UBERON:0000945	71.24	gold quality
descending thoracic aorta	UBERON:0002345	71.04	gold quality
right adrenal gland cortex	UBERON:0035827	70.74	gold quality
heart left ventricle	UBERON:0002084	70.20	gold quality
body of pancreas	UBERON:0001150	69.45	gold quality
right atrium auricular region	UBERON:0006631	69.22	gold quality
liver	UBERON:0002107	69.16	gold quality
Ammon’s horn	UBERON:0001954	68.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.78	gold quality
putamen	UBERON:0001874	68.58	gold quality
left adrenal gland	UBERON:0001234	68.16	gold quality
esophagus mucosa	UBERON:0002469	68.14	gold quality
right frontal lobe	UBERON:0002810	67.58	gold quality
esophagus	UBERON:0001043	67.36	gold quality
cerebral cortex	UBERON:0000956	67.19	gold quality
amygdala	UBERON:0001876	67.18	gold quality
substantia nigra	UBERON:0002038	66.99	gold quality
nucleus accumbens	UBERON:0001882	66.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Germline genetic variation indicates that MIR3065 may play an important role in breast cancer (BC) development and heterogeneity among African-American (AA) women. Further investigation to determine the potential functional effects of these SNPs is warranted. This study contributes to our understanding of BC risk in AA women and highlights the complexity in evaluating variation in gene-dense regions of the human genome. (PMID:29871690)
• miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer. (PMID:34656128)
• Genome stabilityrelated lncRNA ZFPM2AS1 promotes tumor progression via miR30655p/XRCC4 in hepatocellular carcinoma. (PMID:36524359)
• Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p/DLG2 signaling axis. (PMID:38234042)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.