MIR3074

Summary

MIR3074 (microRNA 3074, HGNC:38268) is a microRNA gene on chromosome 9q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422842 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38268
Approved symbol	MIR3074
Name	microRNA 3074
Location	9q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3074
Ensembl gene	ENSG00000207617
Ensembl biotype	miRNA
Entrez	100422842
RNAcentral	URS000075CA56 — miRNA, 81 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384885

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384885 — 1 exons

Exon	Start	End
ENSE00001499892	95086014	95086094

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 72.40.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	72.40	gold quality
endometrium	UBERON:0001295	72.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.17	gold quality
left coronary artery	UBERON:0001626	72.08	gold quality
fundus of stomach	UBERON:0001160	71.76	gold quality
right ovary	UBERON:0002118	71.46	gold quality
islet of Langerhans	UBERON:0000006	71.34	gold quality
ascending aorta	UBERON:0001496	71.20	gold quality
myometrium	UBERON:0001296	71.05	gold quality
body of uterus	UBERON:0009853	71.01	gold quality
body of pancreas	UBERON:0001150	70.42	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.36	gold quality
thoracic aorta	UBERON:0001515	70.16	gold quality
blood	UBERON:0000178	70.04	gold quality
left adrenal gland cortex	UBERON:0035825	69.87	gold quality
muscle of leg	UBERON:0001383	69.75	gold quality
endocervix	UBERON:0000458	69.46	gold quality
tibial artery	UBERON:0007610	69.37	gold quality
esophagus mucosa	UBERON:0002469	68.80	gold quality
heart	UBERON:0000948	68.36	gold quality
skin of abdomen	UBERON:0001416	68.25	gold quality
right atrium auricular region	UBERON:0006631	68.22	gold quality
gastrocnemius	UBERON:0001388	68.05	gold quality
heart left ventricle	UBERON:0002084	67.93	gold quality
right lobe of thyroid gland	UBERON:0001119	67.76	gold quality
stomach	UBERON:0000945	67.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.53	gold quality
body of stomach	UBERON:0001161	67.46	gold quality
amygdala	UBERON:0001876	67.37	gold quality
descending thoracic aorta	UBERON:0002345	66.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Results suggest that microRNAs miR-221-5p, miR-380-3p, miR-556-5p, miR-758-3p and miR-3074-3p are potential diagnostic biomarkers of lupus nephritis in patients with systemic lupus erythematosus (SLE). (PMID:27835701)
• The data suggest a potential contribution of miR-3074-5p in the pathogenesis of recurrent miscarriage by disturbing the normal activities of trophoblast cells. (PMID:28826362)
• Inhibition of retinoic acid receptor alpha phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3. (PMID:33902658)
• miR-3074-5p/CLN8 pathway regulates decidualization in recurrent miscarriage. (PMID:34044364)
• MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage. (PMID:38151653)
• Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression. (PMID:38240925)
• MiR-3074-5p suppresses non-small cell lung cancer progression by targeting the YWHAZ/Hsp27 axis. (PMID:38943969)
• Circ_0006476 modulates macrophage apoptosis through the miR-3074-5p/DLL4 axis: implications for Notch signalling pathway regulation in cardiovascular disease. (PMID:39167432)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-24-4	ENSDARG00000081769
mus_musculus	Mir24-1	ENSMUSG00000105904

Paralogs (2): MIR24-2 (ENSG00000284387), MIR24-1 (ENSG00000284459)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.