MIR3115

Summary

MIR3115 (microRNA 3115, HGNC:38371) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422866 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38371
Approved symbol	MIR3115
Name	microRNA 3115
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3115
Ensembl gene	ENSG00000263793
Ensembl biotype	miRNA
Entrez	100422866
RNAcentral	URS0000759AC2 — ncRNA, 68 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577915

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577915 — 1 exons

Exon	Start	End
ENSE00002707582	23044305	23044372

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 80.89.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.89	gold quality
calcaneal tendon	UBERON:0003701	80.53	gold quality
kidney	UBERON:0002113	79.15	gold quality
blood	UBERON:0000178	78.42	gold quality
monocyte	CL:0000576	74.61	gold quality
lung	UBERON:0002048	73.11	gold quality
gastrocnemius	UBERON:0001388	72.28	gold quality
heart	UBERON:0000948	72.17	gold quality
endometrium	UBERON:0001295	72.14	gold quality
heart left ventricle	UBERON:0002084	71.77	gold quality
putamen	UBERON:0001874	70.72	gold quality
stomach	UBERON:0000945	70.64	gold quality
right atrium auricular region	UBERON:0006631	70.35	gold quality
upper lobe of left lung	UBERON:0008952	69.35	gold quality
adrenal gland	UBERON:0002369	68.36	gold quality
vagina	UBERON:0000996	68.30	gold quality
thoracic aorta	UBERON:0001515	68.24	gold quality
ascending aorta	UBERON:0001496	67.96	gold quality
transverse colon	UBERON:0001157	67.89	gold quality
omental fat pad	UBERON:0010414	67.76	gold quality
left coronary artery	UBERON:0001626	67.24	gold quality
body of uterus	UBERON:0009853	67.24	gold quality
intestine	UBERON:0000160	67.12	gold quality
colon	UBERON:0001155	67.03	gold quality
body of pancreas	UBERON:0001150	66.90	gold quality
tibial artery	UBERON:0007610	66.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.32	gold quality
body of stomach	UBERON:0001161	66.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.