MIR3116-1

Summary

MIR3116-1 (microRNA 3116-1, HGNC:38200) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422902 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38200
Approved symbol	MIR3116-1
Name	microRNA 3116-1
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3116-1
Ensembl gene	ENSG00000263908
Ensembl biotype	miRNA
Entrez	100422902
RNAcentral	URS000075E6EF — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584654

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584654 — 1 exons

Exon	Start	End
ENSE00002695920	62078786	62078859

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 72.01.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	72.01	gold quality
right atrium auricular region	UBERON:0006631	71.87	gold quality
blood	UBERON:0000178	71.60	gold quality
left adrenal gland	UBERON:0001234	71.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.15	gold quality
ectocervix	UBERON:0012249	70.63	gold quality
body of uterus	UBERON:0009853	69.19	gold quality
tibial artery	UBERON:0007610	68.90	gold quality
right lobe of liver	UBERON:0001114	68.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.22	gold quality
esophagus mucosa	UBERON:0002469	68.20	gold quality
transverse colon	UBERON:0001157	67.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.15	gold quality
vagina	UBERON:0000996	66.53	gold quality
ascending aorta	UBERON:0001496	66.15	gold quality
body of stomach	UBERON:0001161	66.14	gold quality
body of pancreas	UBERON:0001150	66.10	gold quality
skin of abdomen	UBERON:0001416	65.29	gold quality
urinary bladder	UBERON:0001255	65.22	gold quality
minor salivary gland	UBERON:0001830	64.96	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.84	gold quality
adult mammalian kidney	UBERON:0000082	64.46	gold quality
tibial nerve	UBERON:0001323	64.32	gold quality
skin of leg	UBERON:0001511	63.93	gold quality
thoracic mammary gland	UBERON:0005200	63.91	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.61	gold quality
left ovary	UBERON:0002119	63.20	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-3116 sensitizes glioma cells to temozolomide by targeting FGFR1 and regulating the FGFR1/PI3K/AKT pathway. (PMID:32181582)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.