MIR3116-2

Summary

MIR3116-2 (microRNA 3116-2, HGNC:38318) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422946 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38318
Approved symbol	MIR3116-2
Name	microRNA 3116-2
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3116-2
Ensembl gene	ENSG00000283690
Ensembl biotype	miRNA
Entrez	100422946
RNAcentral	URS000075BAE4 — miRNA, 68 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636415

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636415 — 1 exons

Exon	Start	End
ENSE00003799465	62078789	62078856

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 73.07.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	73.07	gold quality
gastrocnemius	UBERON:0001388	72.11	gold quality
body of stomach	UBERON:0001161	68.21	gold quality
blood	UBERON:0000178	67.08	gold quality
skin of abdomen	UBERON:0001416	66.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.06	gold quality
right atrium auricular region	UBERON:0006631	65.81	gold quality
skin of leg	UBERON:0001511	65.68	gold quality
esophagus mucosa	UBERON:0002469	65.64	gold quality
body of pancreas	UBERON:0001150	65.44	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.64	gold quality
minor salivary gland	UBERON:0001830	64.57	gold quality
ascending aorta	UBERON:0001496	63.98	gold quality
vagina	UBERON:0000996	63.85	gold quality
tibial nerve	UBERON:0001323	63.30	gold quality
omental fat pad	UBERON:0010414	62.92	gold quality
cerebellar hemisphere	UBERON:0002245	62.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.55	gold quality
prostate gland	UBERON:0002367	60.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.73	gold quality
thyroid gland	UBERON:0002046	59.66	gold quality
tibial artery	UBERON:0007610	59.38	gold quality
left lobe of thyroid gland	UBERON:0001120	59.27	gold quality
pituitary gland	UBERON:0000007	57.98	gold quality
left testis	UBERON:0004533	43.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.