MIR3117

Summary

MIR3117 (microRNA 3117, HGNC:38385) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422871 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38385
Approved symbol	MIR3117
Name	microRNA 3117
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3117
Ensembl gene	ENSG00000264720
Ensembl biotype	miRNA
Entrez	100422871
RNAcentral	URS000075E1C7 — miRNA, 78 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584034

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584034 — 1 exons

Exon	Start	End
ENSE00002724472	66628440	66628517

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 84.71.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	84.71	gold quality
adrenal tissue	UBERON:0018303	81.15	gold quality
calcaneal tendon	UBERON:0003701	80.67	gold quality
prefrontal cortex	UBERON:0000451	80.64	gold quality
endometrium	UBERON:0001295	79.81	gold quality
monocyte	CL:0000576	77.80	gold quality
nucleus accumbens	UBERON:0001882	76.79	gold quality
putamen	UBERON:0001874	76.31	gold quality
caudate nucleus	UBERON:0001873	75.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.57	gold quality
muscle of leg	UBERON:0001383	75.31	gold quality
rectum	UBERON:0001052	74.08	gold quality
heart left ventricle	UBERON:0002084	74.06	gold quality
popliteal artery	UBERON:0002250	73.92	gold quality
tibial artery	UBERON:0007610	73.91	gold quality
blood	UBERON:0000178	73.78	gold quality
heart	UBERON:0000948	73.63	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
substantia nigra	UBERON:0002038	72.84	gold quality
amygdala	UBERON:0001876	72.62	gold quality
kidney	UBERON:0002113	72.59	gold quality
anterior cingulate cortex	UBERON:0009835	72.52	gold quality
brain	UBERON:0000955	72.30	gold quality
Ammon’s horn	UBERON:0001954	71.92	gold quality
adult mammalian kidney	UBERON:0000082	71.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.71	gold quality
spleen	UBERON:0002106	71.66	gold quality
cerebral cortex	UBERON:0000956	71.58	gold quality
hypothalamus	UBERON:0001898	71.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-3117 contributes to the proliferation of HepG2 by targeting PHLPPL. (PMID:27822662)
• Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women. (PMID:33507700)
• Association of MIR3117 and MIR612 Genes Polymorphisms with Childhood Acute Lymphoblastic Leukemia in the Mexican Population. (PMID:36002354)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.