MIR3118-1

Summary

MIR3118-1 (microRNA 3118-1, HGNC:38265) is a microRNA gene on chromosome 21q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423008 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38265
Approved symbol	MIR3118-1
Name	microRNA 3118-1
Location	21q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3118-1
Ensembl gene	ENSG00000266299
Ensembl biotype	miRNA
Entrez	100423008
RNAcentral	URS000078ED7D — miRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581787

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581787 — 1 exons

Exon	Start	End
ENSE00002688762	13644775	13644850

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 80.07.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	80.07	gold quality
endometrium	UBERON:0001295	76.36	gold quality
blood	UBERON:0000178	75.23	gold quality
lymph node	UBERON:0000029	72.12	gold quality
gall bladder	UBERON:0002110	70.76	gold quality
liver	UBERON:0002107	69.95	gold quality
right ovary	UBERON:0002118	69.64	gold quality
adenohypophysis	UBERON:0002196	69.25	gold quality
myometrium	UBERON:0001296	68.63	gold quality
rectum	UBERON:0001052	68.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.98	gold quality
body of stomach	UBERON:0001161	67.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.10	gold quality
heart left ventricle	UBERON:0002084	66.60	gold quality
left coronary artery	UBERON:0001626	66.15	gold quality
tibial artery	UBERON:0007610	66.15	gold quality
zone of skin	UBERON:0000014	65.99	gold quality
right atrium auricular region	UBERON:0006631	65.80	gold quality
skin of leg	UBERON:0001511	65.37	gold quality
transverse colon	UBERON:0001157	65.33	gold quality
adipose tissue	UBERON:0001013	65.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.83	gold quality
ascending aorta	UBERON:0001496	64.68	gold quality
skin of abdomen	UBERON:0001416	64.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.55	gold quality
omental fat pad	UBERON:0010414	64.45	gold quality
upper lobe of left lung	UBERON:0008952	64.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.09	gold quality
gastrocnemius	UBERON:0001388	64.08	gold quality
esophagus mucosa	UBERON:0002469	64.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HAND2-AS1 Works as a ceRNA of miR-3118 to Suppress Proliferation and Migration in Breast Cancer by Upregulating PHLPP2. (PMID:33015182)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.