MIR3118-2

Summary

MIR3118-2 (microRNA 3118-2, HGNC:38324) is a microRNA gene on chromosome 15q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422949 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38324
Approved symbol	MIR3118-2
Name	microRNA 3118-2
Location	15q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3118-2
Ensembl gene	ENSG00000265322
Ensembl biotype	miRNA
Entrez	100422949
RNAcentral	URS000075BF5A — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584700

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584700 — 1 exons

Exon	Start	End
ENSE00002724976	20832795	20832869

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 85.24.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.24	gold quality
duodenum	UBERON:0002114	73.70	gold quality
vermiform appendix	UBERON:0001154	71.67	gold quality
placenta	UBERON:0001987	69.67	gold quality
adrenal tissue	UBERON:0018303	68.16	gold quality
islet of Langerhans	UBERON:0000006	67.10	gold quality
tonsil	UBERON:0002372	66.64	gold quality
endometrium	UBERON:0001295	66.34	gold quality
liver	UBERON:0002107	66.16	gold quality
muscle of leg	UBERON:0001383	64.38	gold quality
monocyte	CL:0000576	64.16	gold quality
fundus of stomach	UBERON:0001160	64.14	gold quality
gastrocnemius	UBERON:0001388	64.09	gold quality
right adrenal gland cortex	UBERON:0035827	63.75	gold quality
heart left ventricle	UBERON:0002084	63.02	gold quality
heart	UBERON:0000948	62.62	gold quality
right atrium auricular region	UBERON:0006631	62.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	62.22	gold quality
right coronary artery	UBERON:0001625	62.10	gold quality
right adrenal gland	UBERON:0001233	61.73	gold quality
left adrenal gland cortex	UBERON:0035825	61.70	gold quality
blood	UBERON:0000178	61.51	gold quality
calcaneal tendon	UBERON:0003701	61.28	gold quality
left adrenal gland	UBERON:0001234	60.30	gold quality
left coronary artery	UBERON:0001626	60.27	gold quality
adult mammalian kidney	UBERON:0000082	60.21	gold quality
spleen	UBERON:0002106	59.64	gold quality
tibial artery	UBERON:0007610	59.04	gold quality
body of stomach	UBERON:0001161	58.81	gold quality
stomach	UBERON:0000945	58.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR3118-4 (ENSG00000265793), MIR3118-3 (ENSG00000277243)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.