MIR3119-1

Summary

MIR3119-1 (microRNA 3119-1, HGNC:38253) is a microRNA gene on chromosome 1q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422839 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38253
Approved symbol	MIR3119-1
Name	microRNA 3119-1
Location	1q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3119-1
Ensembl gene	ENSG00000283340
Ensembl biotype	miRNA
Entrez	100422839
RNAcentral	URS0000759AAD — miRNA, 85 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637673

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637673 — 1 exons

Exon	Start	End
ENSE00003800987	170151378	170151462

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 70.30.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.30	gold quality
heart	UBERON:0000948	67.07	gold quality
right atrium auricular region	UBERON:0006631	66.27	gold quality
heart left ventricle	UBERON:0002084	63.64	gold quality
right frontal lobe	UBERON:0002810	54.52	gold quality
upper lobe of left lung	UBERON:0008952	52.93	gold quality
pituitary gland	UBERON:0000007	51.30	gold quality
left ovary	UBERON:0002119	50.18	gold quality
left testis	UBERON:0004533	34.97	silver quality
right testis	UBERON:0004534	23.91	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.