MIR3120

Summary

MIR3120 (microRNA 3120, HGNC:38295) is a microRNA gene on chromosome 1q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422882 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38295
Approved symbol	MIR3120
Name	microRNA 3120
Location	1q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3120
Ensembl gene	ENSG00000283152
Ensembl biotype	miRNA
OMIM	614722
Entrez	100422882
RNAcentral	URS000075DDE6 — ncRNA, 81 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636555

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636555 — 1 exons

Exon	Start	End
ENSE00003794534	172138808	172138888

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 81.12.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	81.12	gold quality
small intestine	UBERON:0002108	77.86	gold quality
vermiform appendix	UBERON:0001154	75.41	gold quality
muscle of leg	UBERON:0001383	71.49	gold quality
blood	UBERON:0000178	61.28	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.80	gold quality
right atrium auricular region	UBERON:0006631	60.70	gold quality
gastrocnemius	UBERON:0001388	60.58	gold quality
heart left ventricle	UBERON:0002084	58.89	gold quality
cerebellar hemisphere	UBERON:0002245	57.83	gold quality
right frontal lobe	UBERON:0002810	52.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• The results demonstrated miR-3120-5p promotes stemness and invasiveness of colon cancer cells through direct targeting of Axin2. (PMID:29307822)
• The lncRNA WTAPP1, a molecular decoy for miR-3120-5p, regulates MMP-1 expression via the PI3K/Akt and autophagy pathways, thereby mediating cell migration and angiogenesis in EPCs. (PMID:30171660)
• Overexpression of KLF4 significantly reversed the effects of miR31205p on nonsmall cell lung cancer (NSCLC) cell proliferation and invasion. In conclusion, the present study demonstrated that miR31205p promoted NSCLC progression by directly targeting KLF4. (PMID:30221715)
• The microRNA cluster miR-214/miR-3120 prevents tumor cell switching from an epithelial to a mesenchymal-like phenotype and inhibits autophagy in gallbladder cancer. (PMID:33340658)
• Small RNA sequencing to differentiate lung squamous cell carcinomas from metastatic lung tumors from head and neck cancers. (PMID:33668046)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR214 (ENSG00000283844)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.