MIR3121

Summary

MIR3121 (microRNA 3121, HGNC:38259) is a microRNA gene on chromosome 1q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423032 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38259
Approved symbol	MIR3121
Name	microRNA 3121
Location	1q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3121
Ensembl gene	ENSG00000265435
Ensembl biotype	miRNA
Entrez	100423032
RNAcentral	URS000075D174 — miRNA, 77 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579680

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579680 — 1 exons

Exon	Start	End
ENSE00002729445	180438314	180438390

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 97.24.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.24	gold quality
endometrium	UBERON:0001295	75.94	gold quality
kidney	UBERON:0002113	75.76	gold quality
heart	UBERON:0000948	75.68	gold quality
adrenal tissue	UBERON:0018303	75.18	gold quality
lung	UBERON:0002048	73.89	gold quality
blood	UBERON:0000178	73.54	gold quality
intestine	UBERON:0000160	72.47	gold quality
stomach	UBERON:0000945	72.09	gold quality
body of stomach	UBERON:0001161	72.02	gold quality
body of pancreas	UBERON:0001150	69.10	gold quality
transverse colon	UBERON:0001157	68.83	gold quality
skin of abdomen	UBERON:0001416	68.53	gold quality
urinary bladder	UBERON:0001255	68.37	gold quality
colon	UBERON:0001155	68.36	gold quality
ascending aorta	UBERON:0001496	66.99	gold quality
liver	UBERON:0002107	66.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.94	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.06	gold quality
right frontal lobe	UBERON:0002810	63.95	gold quality
skin of leg	UBERON:0001511	63.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.82	gold quality
anterior cingulate cortex	UBERON:0009835	63.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.34	gold quality
vagina	UBERON:0000996	63.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.86	gold quality
left lobe of thyroid gland	UBERON:0001120	62.22	gold quality
left ovary	UBERON:0002119	62.15	gold quality
caudate nucleus	UBERON:0001873	61.91	gold quality
omental fat pad	UBERON:0010414	61.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.