MIR3122

Summary

MIR3122 (microRNA 3122, HGNC:38320) is a microRNA gene on chromosome 1q32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422947 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38320
Approved symbol	MIR3122
Name	microRNA 3122
Location	1q32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3122
Ensembl gene	ENSG00000264358
Ensembl biotype	miRNA
Entrez	100422947
RNAcentral	URS000075D748 — miRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577243

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577243 — 1 exons

Exon	Start	End
ENSE00002698532	212077613	212077685

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 87.18.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	87.18	gold quality
bone marrow	UBERON:0002371	86.05	gold quality
heart	UBERON:0000948	81.32	gold quality
placenta	UBERON:0001987	73.47	gold quality
endometrium	UBERON:0001295	72.69	gold quality
blood	UBERON:0000178	72.61	gold quality
stomach	UBERON:0000945	71.95	gold quality
anterior cingulate cortex	UBERON:0009835	71.57	gold quality
body of pancreas	UBERON:0001150	71.33	gold quality
putamen	UBERON:0001874	69.92	gold quality
heart left ventricle	UBERON:0002084	69.83	gold quality
rectum	UBERON:0001052	68.50	gold quality
right lobe of liver	UBERON:0001114	67.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.53	gold quality
thoracic mammary gland	UBERON:0005200	67.41	gold quality
tonsil	UBERON:0002372	66.64	gold quality
lung	UBERON:0002048	66.29	gold quality
body of stomach	UBERON:0001161	66.12	gold quality
skin of leg	UBERON:0001511	66.06	gold quality
intestine	UBERON:0000160	65.91	gold quality
esophagus mucosa	UBERON:0002469	65.06	gold quality
urinary bladder	UBERON:0001255	64.40	gold quality
minor salivary gland	UBERON:0001830	64.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.15	gold quality
right adrenal gland	UBERON:0001233	64.13	gold quality
skin of abdomen	UBERON:0001416	63.79	gold quality
colon	UBERON:0001155	63.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.31	gold quality
transverse colon	UBERON:0001157	63.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.