MIR3123

Summary

MIR3123 (microRNA 3123, HGNC:38330) is a microRNA gene on chromosome 1q43.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422856 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38330
Approved symbol	MIR3123
Name	microRNA 3123
Location	1q43
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3123
Ensembl gene	ENSG00000265831
Ensembl biotype	miRNA
Entrez	100422856
RNAcentral	URS0000759A78 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583417

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583417 — 1 exons

Exon	Start	End
ENSE00002721340	241132272	241132346

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 76.86.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	76.86	gold quality
blood	UBERON:0000178	75.88	gold quality
monocyte	CL:0000576	74.88	gold quality
left adrenal gland	UBERON:0001234	73.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.17	gold quality
stomach	UBERON:0000945	68.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.59	gold quality
corpus callosum	UBERON:0002336	68.19	gold quality
body of stomach	UBERON:0001161	67.20	gold quality
caudate nucleus	UBERON:0001873	66.12	gold quality
Ammon’s horn	UBERON:0001954	62.84	gold quality
nucleus accumbens	UBERON:0001882	61.90	gold quality
cerebellar hemisphere	UBERON:0002245	61.87	gold quality
right frontal lobe	UBERON:0002810	61.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.17	gold quality
lung	UBERON:0002048	60.05	gold quality
pituitary gland	UBERON:0000007	59.06	gold quality
thyroid gland	UBERON:0002046	50.06	gold quality
testis	UBERON:0000473	42.40	gold quality
left testis	UBERON:0004533	36.41	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.