MIR3124

Summary

MIR3124 (microRNA 3124, HGNC:38262) is a microRNA gene on chromosome 1q44.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422879 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38262
Approved symbol	MIR3124
Name	microRNA 3124
Location	1q44
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3124
Ensembl gene	ENSG00000264500
Ensembl biotype	miRNA
Entrez	100422879
RNAcentral	URS000075A62E — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582636

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582636 — 1 exons

Exon	Start	End
ENSE00002703189	248826377	248826443

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 91.44.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0463 / max 37.6472, expressed in 511 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9655	1.0463	511

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	91.44	gold quality
vermiform appendix	UBERON:0001154	88.06	gold quality
right uterine tube	UBERON:0001302	85.61	gold quality
monocyte	CL:0000576	85.25	gold quality
duodenum	UBERON:0002114	85.25	gold quality
small intestine	UBERON:0002108	82.65	gold quality
bone marrow	UBERON:0002371	82.45	gold quality
placenta	UBERON:0001987	82.29	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.48	gold quality
endometrium	UBERON:0001295	80.74	gold quality
granulocyte	CL:0000094	80.68	gold quality
prefrontal cortex	UBERON:0000451	80.25	gold quality
rectum	UBERON:0001052	79.57	gold quality
blood	UBERON:0000178	79.45	gold quality
adrenal tissue	UBERON:0018303	78.60	gold quality
lymph node	UBERON:0000029	78.50	gold quality
liver	UBERON:0002107	78.13	gold quality
fallopian tube	UBERON:0003889	77.82	gold quality
tonsil	UBERON:0002372	77.51	gold quality
mucosa of transverse colon	UBERON:0004991	77.17	gold quality
right lobe of liver	UBERON:0001114	77.09	gold quality
muscle of leg	UBERON:0001383	77.04	gold quality
intestine	UBERON:0000160	76.68	gold quality
kidney	UBERON:0002113	76.00	gold quality
calcaneal tendon	UBERON:0003701	75.80	gold quality
ectocervix	UBERON:0012249	75.76	gold quality
adult mammalian kidney	UBERON:0000082	75.73	gold quality
gastrocnemius	UBERON:0001388	75.73	gold quality
heart left ventricle	UBERON:0002084	75.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.