MIR3125

Summary

MIR3125 (microRNA 3125, HGNC:38219) is a microRNA gene on chromosome 2p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422986 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38219
Approved symbol	MIR3125
Name	microRNA 3125
Location	2p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3125
Ensembl gene	ENSG00000264370
Ensembl biotype	miRNA
Entrez	100422986
RNAcentral	URS000075E529 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579927

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579927 — 1 exons

Exon	Start	End
ENSE00002713689	12737367	12737444

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 86.68.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	86.68	gold quality
vermiform appendix	UBERON:0001154	85.36	gold quality
duodenum	UBERON:0002114	83.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.13	gold quality
left ovary	UBERON:0002119	81.33	gold quality
ovary	UBERON:0000992	80.11	gold quality
left adrenal gland cortex	UBERON:0035825	79.98	gold quality
sural nerve	UBERON:0015488	79.66	gold quality
adrenal gland	UBERON:0002369	79.35	gold quality
left adrenal gland	UBERON:0001234	79.20	gold quality
blood	UBERON:0000178	78.82	gold quality
placenta	UBERON:0001987	77.90	gold quality
lymph node	UBERON:0000029	77.72	gold quality
apex of heart	UBERON:0002098	77.43	gold quality
heart left ventricle	UBERON:0002084	76.82	gold quality
right ovary	UBERON:0002118	76.81	gold quality
tibial nerve	UBERON:0001323	76.60	gold quality
right adrenal gland	UBERON:0001233	76.34	gold quality
heart	UBERON:0000948	75.98	gold quality
granulocyte	CL:0000094	75.69	gold quality
stomach	UBERON:0000945	75.59	gold quality
body of stomach	UBERON:0001161	75.48	gold quality
right atrium auricular region	UBERON:0006631	75.43	gold quality
kidney	UBERON:0002113	75.12	gold quality
endometrium	UBERON:0001295	74.52	gold quality
fundus of stomach	UBERON:0001160	74.29	gold quality
right adrenal gland cortex	UBERON:0035827	74.09	gold quality
rectum	UBERON:0001052	73.91	gold quality
muscle of leg	UBERON:0001383	73.72	gold quality
tonsil	UBERON:0002372	73.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long Noncoding RNA LINC01207 Promotes Colon Cancer Cell Proliferation and Invasion by Regulating miR-3125/TRIM22 Axis. (PMID:33299853)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.