MIR3126

Summary

MIR3126 (microRNA 3126, HGNC:38225) is a microRNA gene on chromosome 2p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423030 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38225
Approved symbol	MIR3126
Name	microRNA 3126
Location	2p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3126
Ensembl gene	ENSG00000266649
Ensembl biotype	miRNA
Entrez	100423030
RNAcentral	URS000075DA6A — miRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577443

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577443 — 1 exons

Exon	Start	End
ENSE00002709553	69103682	69103755

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 85.69.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.69	gold quality
adrenal tissue	UBERON:0018303	82.24	gold quality
kidney	UBERON:0002113	80.51	gold quality
stomach	UBERON:0000945	79.30	gold quality
blood	UBERON:0000178	78.33	gold quality
monocyte	CL:0000576	76.54	gold quality
lung	UBERON:0002048	75.72	gold quality
endometrium	UBERON:0001295	74.96	gold quality
corpus callosum	UBERON:0002336	71.80	gold quality
islet of Langerhans	UBERON:0000006	71.54	gold quality
heart	UBERON:0000948	71.18	gold quality
gastrocnemius	UBERON:0001388	70.97	gold quality
body of stomach	UBERON:0001161	70.05	gold quality
tibial artery	UBERON:0007610	69.03	gold quality
popliteal artery	UBERON:0002250	68.96	gold quality
left coronary artery	UBERON:0001626	68.91	gold quality
body of pancreas	UBERON:0001150	68.43	gold quality
intestine	UBERON:0000160	67.93	gold quality
descending thoracic aorta	UBERON:0002345	66.99	gold quality
caudate nucleus	UBERON:0001873	66.90	gold quality
heart left ventricle	UBERON:0002084	66.70	gold quality
myometrium	UBERON:0001296	66.49	gold quality
thoracic aorta	UBERON:0001515	66.42	gold quality
ascending aorta	UBERON:0001496	66.32	gold quality
left adrenal gland	UBERON:0001234	66.21	gold quality
skin of abdomen	UBERON:0001416	65.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.53	gold quality
anterior cingulate cortex	UBERON:0009835	65.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.33	gold quality
upper lobe of left lung	UBERON:0008952	64.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The study identified a 3-miRNA panel (miR-92-3p, miR-107, and miR-3126-5p) as valuable diagnostic marker for hepatocellular carcinoma (PMID:28079796)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.