MIR3127

Summary

MIR3127 (microRNA 3127, HGNC:38269) is a microRNA gene on chromosome 2q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422928 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38269
Approved symbol	MIR3127
Name	microRNA 3127
Location	2q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3127
Ensembl gene	ENSG00000264157
Ensembl biotype	miRNA
Entrez	100422928
RNAcentral	URS000075DB87 — miRNA, 76 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583925

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583925 — 1 exons

Exon	Start	End
ENSE00002695933	96798278	96798353

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 82.88.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	82.88	gold quality
monocyte	CL:0000576	76.47	gold quality
adrenal tissue	UBERON:0018303	75.49	gold quality
blood	UBERON:0000178	74.74	gold quality
muscle of leg	UBERON:0001383	74.11	gold quality
islet of Langerhans	UBERON:0000006	72.80	gold quality
gastrocnemius	UBERON:0001388	72.62	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.74	gold quality
mucosa of stomach	UBERON:0001199	68.98	gold quality
Ammon’s horn	UBERON:0001954	68.42	gold quality
heart left ventricle	UBERON:0002084	68.40	gold quality
tibial artery	UBERON:0007610	68.20	gold quality
endometrium	UBERON:0001295	68.17	gold quality
body of stomach	UBERON:0001161	68.08	gold quality
adult mammalian kidney	UBERON:0000082	67.92	gold quality
stomach	UBERON:0000945	67.86	gold quality
right lobe of liver	UBERON:0001114	67.86	gold quality
transverse colon	UBERON:0001157	67.23	gold quality
liver	UBERON:0002107	66.96	gold quality
colon	UBERON:0001155	66.86	gold quality
granulocyte	CL:0000094	66.74	gold quality
rectum	UBERON:0001052	66.71	gold quality
ascending aorta	UBERON:0001496	66.48	gold quality
putamen	UBERON:0001874	66.26	gold quality
fundus of stomach	UBERON:0001160	66.21	gold quality
right atrium auricular region	UBERON:0006631	66.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.07	gold quality
body of pancreas	UBERON:0001150	66.00	gold quality
left coronary artery	UBERON:0001626	65.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. (PMID:25284075)
• MiR-3127 overexpression promoted HCC cell proliferation in vitro and tumor growth in vivo. (PMID:25849943)
• mir- 3127-5p, one of up-regulated miRNAs, exhibits low expression level in several Hepatocellular Carcinoma Cells cell lines and its overexpression could inhibit cell growth of Bel-7402 and Hep3B cell lines by inducing S phase arrest by up-regulating the expression of p21and P27 and repressing the PI3K/Akt pathway. (PMID:28351032)
• Downregulation of miR-3127-5p promotes EMT through activating the Wnt/FZD4/beta-catenin signaling pathway. (PMID:29566281)
• This study elucidated that GACAT3/miR-3127-5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target. (PMID:30317610)
• LINC00319 promotes migration, invasion and epithelial-mesenchymal transition process in cervical cancer by regulating miR-3127-5p/RPP25 axis. (PMID:31942724)
• Metformin Affects Paclitaxel Sensitivity of Ovarian Cancer Cells Through Autophagy Mediated by Long Noncoding RNASNHG7/miR-3127-5p Axis. (PMID:32522016)
• LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis. (PMID:34226413)
• Long non-coding RNA PVT1/microRNA miR-3127-5p/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells. (PMID:34898354)
• CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis. (PMID:34978042)
• CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis. (PMID:38805063)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.