MIR3128

Summary

MIR3128 (microRNA 3128, HGNC:38188) is a microRNA gene on chromosome 2q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422824 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38188
Approved symbol	MIR3128
Name	microRNA 3128
Location	2q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3128
Ensembl gene	ENSG00000265396
Ensembl biotype	miRNA
Entrez	100422824
RNAcentral	URS000075A709 — ncRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581957

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581957 — 1 exons

Exon	Start	End
ENSE00002730747	177255945	177256010

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 89.33.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.33	gold quality
vermiform appendix	UBERON:0001154	84.88	gold quality
adrenal tissue	UBERON:0018303	84.13	gold quality
bone marrow	UBERON:0002371	80.87	gold quality
placenta	UBERON:0001987	79.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.47	gold quality
monocyte	CL:0000576	76.39	gold quality
blood	UBERON:0000178	76.35	gold quality
kidney	UBERON:0002113	76.08	gold quality
endometrium	UBERON:0001295	74.90	gold quality
liver	UBERON:0002107	74.31	gold quality
gastrocnemius	UBERON:0001388	73.68	gold quality
islet of Langerhans	UBERON:0000006	73.11	gold quality
calcaneal tendon	UBERON:0003701	72.76	gold quality
stomach	UBERON:0000945	71.74	gold quality
Ammon’s horn	UBERON:0001954	71.44	gold quality
adrenal gland	UBERON:0002369	70.75	gold quality
right ovary	UBERON:0002118	70.40	gold quality
anterior cingulate cortex	UBERON:0009835	69.76	gold quality
body of stomach	UBERON:0001161	69.72	gold quality
heart left ventricle	UBERON:0002084	69.26	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.99	gold quality
heart	UBERON:0000948	68.92	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.81	gold quality
popliteal artery	UBERON:0002250	68.52	gold quality
tibial artery	UBERON:0007610	68.50	gold quality
fundus of stomach	UBERON:0001160	68.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.42	gold quality
amygdala	UBERON:0001876	68.38	gold quality
lung	UBERON:0002048	68.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.