MIR3129

Summary

MIR3129 (microRNA 3129, HGNC:38217) is a microRNA gene on chromosome 2q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422908 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38217
Approved symbol	MIR3129
Name	microRNA 3129
Location	2q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3129
Ensembl gene	ENSG00000264725
Ensembl biotype	miRNA
Entrez	100422908
RNAcentral	URS000075992D — miRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581095

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581095 — 1 exons

Exon	Start	End
ENSE00002732444	189133036	189133111

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 77.89.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	77.89	gold quality
kidney	UBERON:0002113	77.57	gold quality
adrenal tissue	UBERON:0018303	75.49	gold quality
stomach	UBERON:0000945	75.39	gold quality
lung	UBERON:0002048	72.90	gold quality
muscle of leg	UBERON:0001383	71.79	gold quality
gastrocnemius	UBERON:0001388	70.88	gold quality
blood	UBERON:0000178	70.69	gold quality
calcaneal tendon	UBERON:0003701	70.65	gold quality
right lobe of liver	UBERON:0001114	70.41	gold quality
intestine	UBERON:0000160	68.95	gold quality
endocervix	UBERON:0000458	68.44	gold quality
right atrium auricular region	UBERON:0006631	68.39	gold quality
left coronary artery	UBERON:0001626	67.61	gold quality
tibial artery	UBERON:0007610	67.34	gold quality
popliteal artery	UBERON:0002250	67.24	gold quality
thoracic mammary gland	UBERON:0005200	67.21	gold quality
body of stomach	UBERON:0001161	67.12	gold quality
minor salivary gland	UBERON:0001830	66.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.52	gold quality
omental fat pad	UBERON:0010414	66.49	gold quality
ascending aorta	UBERON:0001496	66.39	gold quality
thoracic aorta	UBERON:0001515	66.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.02	gold quality
left adrenal gland	UBERON:0001234	64.97	gold quality
colon	UBERON:0001155	64.39	gold quality
esophagus mucosa	UBERON:0002469	64.09	gold quality
skin of leg	UBERON:0001511	63.96	gold quality
vagina	UBERON:0000996	63.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• QRT-PCR revealed that hsa-miR-3129 was substantially downregulated in EOC cell lines. In SK-OV-3 and CAOV-3 cells, lentivirus-induced hsa-miR-3129 upregulation downregulated CD44 whereas hsa-miR-3129 downregulation did not affect CD44 expression. (PMID:29915283)
• LncRNA MALAT1 mediates doxorubicin resistance of hepatocellular carcinoma by regulating miR-3129-5p/Nova1 axis. (PMID:32965597)
• Elevated serum miR-3129-5p contributes to the progression of coronary heart disease via targeting mTOR. (PMID:33336524)
• Tumor cells derived-extracellular vesicles transfer miR-3129 to promote hepatocellular carcinoma metastasis by targeting TXNIP. (PMID:33563583)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.