MIR3130-1

Summary

MIR3130-1 (microRNA 3130-1, HGNC:38275) is a microRNA gene on chromosome 2q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422993 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38275
Approved symbol	MIR3130-1
Name	microRNA 3130-1
Location	2q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3130-1, hsa-mir-3130-3
Ensembl gene	ENSG00000283469
Ensembl biotype	miRNA
Entrez	100422993
RNAcentral	URS000075E216 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637816

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637816 — 1 exons

Exon	Start	End
ENSE00003796367	206783234	206783308

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 78.79.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.79	gold quality
monocyte	CL:0000576	73.43	gold quality
kidney	UBERON:0002113	68.62	gold quality
blood	UBERON:0000178	66.97	gold quality
mucosa of stomach	UBERON:0001199	66.70	gold quality
calcaneal tendon	UBERON:0003701	66.27	gold quality
islet of Langerhans	UBERON:0000006	65.17	gold quality
popliteal artery	UBERON:0002250	64.81	gold quality
pancreas	UBERON:0001264	64.38	gold quality
tibial artery	UBERON:0007610	64.27	gold quality
body of pancreas	UBERON:0001150	62.47	gold quality
caudate nucleus	UBERON:0001873	62.03	gold quality
liver	UBERON:0002107	61.53	gold quality
endocervix	UBERON:0000458	60.76	gold quality
thoracic aorta	UBERON:0001515	60.33	gold quality
heart left ventricle	UBERON:0002084	60.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.04	gold quality
ascending aorta	UBERON:0001496	59.79	gold quality
thoracic mammary gland	UBERON:0005200	59.57	gold quality
lower esophagus mucosa	UBERON:0035834	59.30	gold quality
myometrium	UBERON:0001296	59.29	gold quality
gastrocnemius	UBERON:0001388	59.19	gold quality
right adrenal gland cortex	UBERON:0035827	59.15	gold quality
body of stomach	UBERON:0001161	58.70	gold quality
skin of abdomen	UBERON:0001416	58.62	gold quality
ectocervix	UBERON:0012249	58.42	gold quality
minor salivary gland	UBERON:0001830	57.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.40	gold quality
esophagus mucosa	UBERON:0002469	57.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01096 knockdown inhibits progression of triple-negative breast cancer by increasing miR-3130-3p. (PMID:31539132)
• The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer. (PMID:37114256)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.