MIR3131

Summary

MIR3131 (microRNA 3131, HGNC:38347) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422957 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38347
Approved symbol	MIR3131
Name	microRNA 3131
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3131
Ensembl gene	ENSG00000264755
Ensembl biotype	miRNA
Entrez	100422957
RNAcentral	URS000075DAEA — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583592

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583592 — 1 exons

Exon	Start	End
ENSE00002715650	219058688	219058750

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 93.00.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	93.00	gold quality
duodenum	UBERON:0002114	92.75	gold quality
mucosa of transverse colon	UBERON:0004991	89.80	gold quality
transverse colon	UBERON:0001157	88.33	gold quality
colon	UBERON:0001155	86.26	gold quality
endometrium	UBERON:0001295	86.17	gold quality
vermiform appendix	UBERON:0001154	85.31	gold quality
intestine	UBERON:0000160	84.56	gold quality
stomach	UBERON:0000945	83.54	gold quality
body of stomach	UBERON:0001161	82.98	gold quality
small intestine	UBERON:0002108	80.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	79.79	gold quality
adrenal tissue	UBERON:0018303	78.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.16	gold quality
fundus of stomach	UBERON:0001160	77.68	gold quality
right atrium auricular region	UBERON:0006631	75.68	gold quality
anterior cingulate cortex	UBERON:0009835	75.42	gold quality
multicellular organism	UBERON:0000468	74.57	gold quality
right lobe of liver	UBERON:0001114	73.89	gold quality
blood	UBERON:0000178	73.85	gold quality
muscle of leg	UBERON:0001383	73.60	gold quality
kidney	UBERON:0002113	73.60	gold quality
gall bladder	UBERON:0002110	72.93	gold quality
heart	UBERON:0000948	72.77	gold quality
gastrocnemius	UBERON:0001388	72.63	gold quality
body of uterus	UBERON:0009853	71.86	gold quality
liver	UBERON:0002107	71.80	gold quality
adult mammalian kidney	UBERON:0000082	71.46	gold quality
islet of Langerhans	UBERON:0000006	70.84	gold quality
smooth muscle tissue	UBERON:0001135	70.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• human genome-wide gene expression profile assay was used to screen the targets of miR-3131. The overexpressed miR-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level. (PMID:28034876)
• The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer. (PMID:31490768)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.