MIR3132

Summary

MIR3132 (microRNA 3132, HGNC:38373) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423039 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38373
Approved symbol	MIR3132
Name	microRNA 3132
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3132
Ensembl gene	ENSG00000265252
Ensembl biotype	miRNA
Entrez	100423039
RNAcentral	URS000075E739 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581997

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581997 — 1 exons

Exon	Start	End
ENSE00002700426	219549073	219549147

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 88.41.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.41	gold quality
skeletal muscle tissue	UBERON:0001134	87.67	gold quality
left ovary	UBERON:0002119	83.50	gold quality
ovary	UBERON:0000992	83.11	gold quality
apex of heart	UBERON:0002098	82.62	gold quality
right ovary	UBERON:0002118	81.80	gold quality
muscle of leg	UBERON:0001383	77.63	gold quality
gastrocnemius	UBERON:0001388	77.03	gold quality
endometrium	UBERON:0001295	76.61	gold quality
heart left ventricle	UBERON:0002084	76.44	gold quality
right atrium auricular region	UBERON:0006631	75.87	gold quality
heart	UBERON:0000948	75.67	gold quality
blood	UBERON:0000178	75.47	gold quality
urinary bladder	UBERON:0001255	74.22	gold quality
pancreas	UBERON:0001264	73.58	gold quality
body of pancreas	UBERON:0001150	73.53	gold quality
left uterine tube	UBERON:0001303	73.36	gold quality
placenta	UBERON:0001987	72.81	gold quality
pituitary gland	UBERON:0000007	72.62	gold quality
islet of Langerhans	UBERON:0000006	72.25	gold quality
stomach	UBERON:0000945	71.18	gold quality
body of stomach	UBERON:0001161	70.82	gold quality
fallopian tube	UBERON:0003889	70.75	gold quality
adenohypophysis	UBERON:0002196	70.27	gold quality
right testis	UBERON:0004534	70.21	gold quality
smooth muscle tissue	UBERON:0001135	70.08	gold quality
tonsil	UBERON:0002372	70.04	gold quality
testis	UBERON:0000473	69.97	gold quality
lower esophagus	UBERON:0013473	69.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.