MIR3133

Summary

MIR3133 (microRNA 3133, HGNC:38305) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422942 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38305
Approved symbol	MIR3133
Name	microRNA 3133
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3133
Ensembl gene	ENSG00000263752
Ensembl biotype	miRNA
Entrez	100422942
RNAcentral	URS000075CC6A — ncRNA, 78 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583157 — 1 exons

Exon	Start	End
ENSE00002698330	241477905	241477982

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 82.13.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.13	gold quality
blood	UBERON:0000178	78.01	gold quality
endometrium	UBERON:0001295	74.62	gold quality
liver	UBERON:0002107	71.40	gold quality
islet of Langerhans	UBERON:0000006	70.98	gold quality
heart left ventricle	UBERON:0002084	70.67	gold quality
gastrocnemius	UBERON:0001388	70.63	gold quality
right lobe of liver	UBERON:0001114	69.17	gold quality
myometrium	UBERON:0001296	68.10	gold quality
fundus of stomach	UBERON:0001160	67.92	gold quality
right adrenal gland	UBERON:0001233	67.79	gold quality
tibial artery	UBERON:0007610	67.78	gold quality
popliteal artery	UBERON:0002250	67.74	gold quality
body of pancreas	UBERON:0001150	67.30	gold quality
left coronary artery	UBERON:0001626	67.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.05	gold quality
stomach	UBERON:0000945	67.02	gold quality
body of stomach	UBERON:0001161	66.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.99	gold quality
left uterine tube	UBERON:0001303	65.97	gold quality
lower esophagus	UBERON:0013473	65.81	gold quality
descending thoracic aorta	UBERON:0002345	65.60	gold quality
anterior cingulate cortex	UBERON:0009835	65.15	gold quality
thoracic aorta	UBERON:0001515	64.89	gold quality
ascending aorta	UBERON:0001496	64.86	gold quality
left adrenal gland cortex	UBERON:0035825	64.79	gold quality
esophagus	UBERON:0001043	64.67	gold quality
right atrium auricular region	UBERON:0006631	64.60	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR3133 inhibits proliferation and angiogenesis by targeting the JUNB/VEGF pathway in human umbilical vein endothelial cells. (PMID:32945523)
• lncRNA RHPN1-AS1 Serves as a Sponge for miR-3133 Modulating the Cell Proliferation of Retinoblastoma through JAK2. (PMID:33426053)
• miR-3133 is an unfavorable prognosis factor and tumor suppressor in colon cancer. (PMID:37079151)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.