MIR3134

Summary

MIR3134 (microRNA 3134, HGNC:38254) is a microRNA gene on chromosome 3p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422990 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38254
Approved symbol	MIR3134
Name	microRNA 3134
Location	3p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3134
Ensembl gene	ENSG00000264354
Ensembl biotype	miRNA
Entrez	100422990
RNAcentral	URS000075C0FD — ncRNA, 74 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579433 — 1 exons

Exon	Start	End
ENSE00002688390	15697298	15697371

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 77.14.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.14	gold quality
blood	UBERON:0000178	74.60	gold quality
putamen	UBERON:0001874	73.77	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
calcaneal tendon	UBERON:0003701	72.52	gold quality
gall bladder	UBERON:0002110	70.92	gold quality
kidney	UBERON:0002113	70.76	gold quality
endometrium	UBERON:0001295	70.39	gold quality
liver	UBERON:0002107	70.28	gold quality
stomach	UBERON:0000945	70.17	gold quality
heart	UBERON:0000948	68.97	gold quality
lung	UBERON:0002048	68.45	gold quality
body of stomach	UBERON:0001161	68.37	gold quality
left coronary artery	UBERON:0001626	68.13	gold quality
tibial artery	UBERON:0007610	67.95	gold quality
popliteal artery	UBERON:0002250	67.91	gold quality
heart left ventricle	UBERON:0002084	66.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.84	gold quality
anterior cingulate cortex	UBERON:0009835	66.36	gold quality
right frontal lobe	UBERON:0002810	66.30	gold quality
thoracic aorta	UBERON:0001515	66.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.84	gold quality
ascending aorta	UBERON:0001496	65.67	gold quality
colon	UBERON:0001155	65.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.26	gold quality
intestine	UBERON:0000160	65.10	gold quality
transverse colon	UBERON:0001157	65.07	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality
left ovary	UBERON:0002119	64.82	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• An analysis of the global gene expression profile of breast cancer cell line MCF7 overexpressing miR-3134 revealed the presence of at least one AUUUA element in the 3’-UTRs of 63% of miR-3134 regulated protein coding genes. (PMID:23823647)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.