MIR3135A

Summary

MIR3135A (microRNA 3135a, HGNC:38199) is a microRNA gene on chromosome 3p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422901 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38199
Approved symbol	MIR3135A
Name	microRNA 3135a
Location	3p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3135
Ensembl gene	ENSG00000266745
Ensembl biotype	miRNA
Entrez	100422901
RNAcentral	URS000075BB61 — miRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578460

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578460 — 1 exons

Exon	Start	End
ENSE00002731763	20137565	20137641

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 70.79.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.79	gold quality
gastrocnemius	UBERON:0001388	70.69	gold quality
heart left ventricle	UBERON:0002084	67.59	gold quality
ascending aorta	UBERON:0001496	67.06	gold quality
minor salivary gland	UBERON:0001830	66.91	gold quality
body of pancreas	UBERON:0001150	65.20	gold quality
thoracic aorta	UBERON:0001515	65.13	gold quality
tibial artery	UBERON:0007610	65.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.94	gold quality
left coronary artery	UBERON:0001626	64.39	gold quality
body of uterus	UBERON:0009853	64.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.23	gold quality
Ammon’s horn	UBERON:0001954	64.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.91	gold quality
skin of abdomen	UBERON:0001416	63.81	gold quality
omental fat pad	UBERON:0010414	63.16	gold quality
transverse colon	UBERON:0001157	62.91	gold quality
skin of leg	UBERON:0001511	62.87	gold quality
upper lobe of left lung	UBERON:0008952	62.67	gold quality
stomach	UBERON:0000945	62.66	gold quality
hypothalamus	UBERON:0001898	61.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.95	gold quality
thoracic mammary gland	UBERON:0005200	61.49	gold quality
multicellular organism	UBERON:0000468	61.46	gold quality
putamen	UBERON:0001874	61.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.86	gold quality
left lobe of thyroid gland	UBERON:0001120	60.18	gold quality
right atrium auricular region	UBERON:0006631	60.07	gold quality
esophagus mucosa	UBERON:0002469	60.06	gold quality
body of stomach	UBERON:0001161	59.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.