MIR3135B

Summary

MIR3135B (microRNA 3135b, HGNC:41783) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616218 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41783
Approved symbol	MIR3135B
Name	microRNA 3135b
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3135b
Ensembl gene	ENSG00000263649
Ensembl biotype	miRNA
Entrez	100616218
RNAcentral	URS000075A910 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581098

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581098 — 1 exons

Exon	Start	End
ENSE00002688879	32749912	32749979

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 76.39.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Ammon’s horn	UBERON:0001954	76.39	gold quality
gastrocnemius	UBERON:0001388	73.79	gold quality
stomach	UBERON:0000945	73.14	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.41	gold quality
upper lobe of left lung	UBERON:0008952	66.89	gold quality
skin of leg	UBERON:0001511	66.54	gold quality
body of uterus	UBERON:0009853	65.40	gold quality
skin of abdomen	UBERON:0001416	65.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.29	gold quality
esophagus mucosa	UBERON:0002469	63.85	gold quality
thyroid gland	UBERON:0002046	63.63	gold quality
transverse colon	UBERON:0001157	63.62	gold quality
left coronary artery	UBERON:0001626	63.11	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.75	gold quality
caudate nucleus	UBERON:0001873	62.45	gold quality
tibial nerve	UBERON:0001323	60.41	gold quality
vagina	UBERON:0000996	56.34	gold quality
left testis	UBERON:0004533	46.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Circulating miR-3135b and miR-107 are potential biomarkers for severe hypertension. (PMID:32327699)
• Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic regulators for serum lipids and blood glucose in gestational diabetes mellitus. (PMID:34126831)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.