MIR3136

Summary

MIR3136 (microRNA 3136, HGNC:38340) is a microRNA gene on chromosome 3p14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422859 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38340
Approved symbol	MIR3136
Name	microRNA 3136
Location	3p14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3136
Ensembl gene	ENSG00000265355
Ensembl biotype	miRNA
Entrez	100422859
RNAcentral	URS000075A0FD — miRNA, 78 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583498

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583498 — 1 exons

Exon	Start	End
ENSE00002700471	69048958	69049035

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 87.14.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	87.14	gold quality
vermiform appendix	UBERON:0001154	85.89	gold quality
adrenal tissue	UBERON:0018303	84.80	gold quality
blood	UBERON:0000178	80.42	gold quality
endometrium	UBERON:0001295	78.18	gold quality
placenta	UBERON:0001987	76.62	gold quality
monocyte	CL:0000576	75.32	gold quality
right adrenal gland cortex	UBERON:0035827	75.28	gold quality
islet of Langerhans	UBERON:0000006	74.54	gold quality
prefrontal cortex	UBERON:0000451	74.11	gold quality
lymph node	UBERON:0000029	73.72	gold quality
liver	UBERON:0002107	73.61	gold quality
kidney	UBERON:0002113	73.51	gold quality
gastrocnemius	UBERON:0001388	72.98	gold quality
right adrenal gland	UBERON:0001233	72.49	gold quality
stomach	UBERON:0000945	71.04	gold quality
urinary bladder	UBERON:0001255	70.15	gold quality
adult mammalian kidney	UBERON:0000082	69.87	gold quality
heart	UBERON:0000948	69.72	gold quality
right atrium auricular region	UBERON:0006631	69.51	gold quality
body of pancreas	UBERON:0001150	69.47	gold quality
Ammon’s horn	UBERON:0001954	68.61	gold quality
gall bladder	UBERON:0002110	68.53	gold quality
right lung	UBERON:0002167	68.46	gold quality
body of stomach	UBERON:0001161	68.42	gold quality
heart left ventricle	UBERON:0002084	68.42	gold quality
tibial artery	UBERON:0007610	68.08	gold quality
lung	UBERON:0002048	67.38	gold quality
intestine	UBERON:0000160	67.37	gold quality
granulocyte	CL:0000094	67.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.