MIR3137

Summary

MIR3137 (microRNA 3137, HGNC:38263) is a microRNA gene on chromosome 3q29.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422926 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38263
Approved symbol	MIR3137
Name	microRNA 3137
Location	3q29
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3137
Ensembl gene	ENSG00000265333
Ensembl biotype	miRNA
Entrez	100422926
RNAcentral	URS000075C865 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577367

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577367 — 1 exons

Exon	Start	End
ENSE00002711175	195134506	195134580

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 88.33.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.33	gold quality
calcaneal tendon	UBERON:0003701	82.14	gold quality
adrenal tissue	UBERON:0018303	78.75	gold quality
blood	UBERON:0000178	76.49	gold quality
muscle of leg	UBERON:0001383	76.23	gold quality
monocyte	CL:0000576	76.15	gold quality
tonsil	UBERON:0002372	75.74	gold quality
heart	UBERON:0000948	73.79	gold quality
gastrocnemius	UBERON:0001388	73.14	gold quality
right atrium auricular region	UBERON:0006631	70.28	gold quality
islet of Langerhans	UBERON:0000006	69.99	gold quality
stomach	UBERON:0000945	69.96	gold quality
tibial artery	UBERON:0007610	68.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.07	gold quality
body of stomach	UBERON:0001161	67.17	gold quality
lung	UBERON:0002048	67.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.14	gold quality
ectocervix	UBERON:0012249	65.93	gold quality
left adrenal gland cortex	UBERON:0035825	65.85	gold quality
transverse colon	UBERON:0001157	65.45	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.43	gold quality
heart left ventricle	UBERON:0002084	65.29	gold quality
ascending aorta	UBERON:0001496	65.06	gold quality
substantia nigra	UBERON:0002038	64.90	gold quality
body of uterus	UBERON:0009853	64.81	gold quality
colon	UBERON:0001155	64.49	gold quality
omental fat pad	UBERON:0010414	64.31	gold quality
esophagus mucosa	UBERON:0002469	64.09	gold quality
nucleus accumbens	UBERON:0001882	63.95	gold quality
myometrium	UBERON:0001296	63.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Urinary miR-3137 and miR-4270 as potential biomarkers for diabetic kidney disease. (PMID:32869917)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.