MIR3138

Summary

MIR3138 (microRNA 3138, HGNC:38341) is a microRNA gene on chromosome 4p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423011 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38341
Approved symbol	MIR3138
Name	microRNA 3138
Location	4p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3138
Ensembl gene	ENSG00000264931
Ensembl biotype	miRNA
Entrez	100423011
RNAcentral	URS000075E93A — miRNA, 82 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585238

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585238 — 1 exons

Exon	Start	End
ENSE00002691717	10078611	10078692

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 85.34.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	85.34	gold quality
sural nerve	UBERON:0015488	85.34	gold quality
vermiform appendix	UBERON:0001154	83.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.22	gold quality
duodenum	UBERON:0002114	81.46	gold quality
blood	UBERON:0000178	78.99	gold quality
granulocyte	CL:0000094	78.73	gold quality
monocyte	CL:0000576	77.64	gold quality
lymph node	UBERON:0000029	77.48	gold quality
placenta	UBERON:0001987	77.13	gold quality
left uterine tube	UBERON:0001303	75.28	gold quality
lower esophagus mucosa	UBERON:0035834	74.64	gold quality
adrenal tissue	UBERON:0018303	73.85	gold quality
fallopian tube	UBERON:0003889	73.62	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.35	gold quality
muscle of leg	UBERON:0001383	73.32	gold quality
stomach	UBERON:0000945	72.94	gold quality
right atrium auricular region	UBERON:0006631	72.91	gold quality
gastrocnemius	UBERON:0001388	72.78	gold quality
body of stomach	UBERON:0001161	72.57	gold quality
gall bladder	UBERON:0002110	72.47	gold quality
heart	UBERON:0000948	72.42	gold quality
right adrenal gland cortex	UBERON:0035827	72.41	gold quality
heart left ventricle	UBERON:0002084	72.28	gold quality
right adrenal gland	UBERON:0001233	71.68	gold quality
liver	UBERON:0002107	71.59	gold quality
esophagus mucosa	UBERON:0002469	71.48	gold quality
smooth muscle tissue	UBERON:0001135	71.23	gold quality
adult mammalian kidney	UBERON:0000082	71.11	gold quality
descending thoracic aorta	UBERON:0002345	70.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric dysembryoplastic neuroepithelial tumors (PMID:26698155)
• MiR-3138 deteriorates the insulin resistance of HUVECs via KSR2/AMPK/GLUT4 signaling pathway. (PMID:33509040)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.