MIR3139

Summary

MIR3139 (microRNA 3139, HGNC:38201) is a microRNA gene on chromosome 4q31.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423017 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38201
Approved symbol	MIR3139
Name	microRNA 3139
Location	4q31.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3139
Ensembl gene	ENSG00000265623
Ensembl biotype	miRNA
Entrez	100423017
RNAcentral	URS000075D4BC — ncRNA, 76 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579145

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579145 — 1 exons

Exon	Start	End
ENSE00002712401	143343460	143343535

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 96.82.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	96.82	gold quality
blood	UBERON:0000178	83.15	gold quality
bone marrow	UBERON:0002371	81.84	gold quality
liver	UBERON:0002107	81.66	gold quality
adrenal tissue	UBERON:0018303	81.24	gold quality
calcaneal tendon	UBERON:0003701	80.91	gold quality
kidney	UBERON:0002113	80.65	gold quality
stomach	UBERON:0000945	78.24	gold quality
monocyte	CL:0000576	76.81	gold quality
endometrium	UBERON:0001295	76.24	gold quality
lung	UBERON:0002048	76.21	gold quality
ectocervix	UBERON:0012249	76.15	gold quality
adrenal gland	UBERON:0002369	76.09	gold quality
muscle of leg	UBERON:0001383	75.61	gold quality
heart	UBERON:0000948	75.35	gold quality
adult mammalian kidney	UBERON:0000082	72.77	gold quality
gastrocnemius	UBERON:0001388	72.38	gold quality
prefrontal cortex	UBERON:0000451	71.22	gold quality
heart left ventricle	UBERON:0002084	69.50	gold quality
intestine	UBERON:0000160	69.30	gold quality
body of pancreas	UBERON:0001150	68.94	gold quality
left coronary artery	UBERON:0001626	68.75	gold quality
colon	UBERON:0001155	68.27	gold quality
upper lobe of left lung	UBERON:0008952	67.92	gold quality
urinary bladder	UBERON:0001255	67.32	gold quality
body of stomach	UBERON:0001161	67.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.77	gold quality
granulocyte	CL:0000094	66.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.