MIR3140

Summary

MIR3140 (microRNA 3140, HGNC:38183) is a microRNA gene on chromosome 4q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422896 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38183
Approved symbol	MIR3140
Name	microRNA 3140
Location	4q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3140
Ensembl gene	ENSG00000264678
Ensembl biotype	miRNA
Entrez	100422896
RNAcentral	URS000075E6D4 — miRNA, 90 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583685

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583685 — 1 exons

Exon	Start	End
ENSE00002720712	152489327	152489416

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 95.76.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.76	gold quality
liver	UBERON:0002107	87.71	gold quality
kidney	UBERON:0002113	87.24	gold quality
adrenal tissue	UBERON:0018303	86.80	gold quality
blood	UBERON:0000178	84.67	gold quality
corpus callosum	UBERON:0002336	83.46	gold quality
stomach	UBERON:0000945	82.20	gold quality
adult mammalian kidney	UBERON:0000082	82.04	gold quality
calcaneal tendon	UBERON:0003701	80.30	gold quality
bone marrow	UBERON:0002371	78.56	gold quality
heart	UBERON:0000948	77.48	gold quality
endometrium	UBERON:0001295	76.54	gold quality
monocyte	CL:0000576	76.30	gold quality
lung	UBERON:0002048	75.93	gold quality
gastrocnemius	UBERON:0001388	74.53	gold quality
intestine	UBERON:0000160	73.76	gold quality
body of stomach	UBERON:0001161	72.53	gold quality
colon	UBERON:0001155	72.02	gold quality
islet of Langerhans	UBERON:0000006	71.42	gold quality
right atrium auricular region	UBERON:0006631	68.95	gold quality
transverse colon	UBERON:0001157	68.12	gold quality
body of pancreas	UBERON:0001150	68.07	gold quality
tibial artery	UBERON:0007610	67.95	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.60	gold quality
thoracic aorta	UBERON:0001515	67.59	gold quality
ascending aorta	UBERON:0001496	67.55	gold quality
heart left ventricle	UBERON:0002084	67.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.75	gold quality
esophagus mucosa	UBERON:0002469	66.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Hypoxiainduced circCCDC66 promotes the tumorigenesis of colorectal cancer via the miR3140/autophagy pathway. (PMID:33125087)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.