MIR3142

Summary

MIR3142 (microRNA 3142, HGNC:38297) is a microRNA gene on chromosome 5q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422938 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38297
Approved symbol	MIR3142
Name	microRNA 3142
Location	5q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3142
Ensembl gene	ENSG00000265237
Ensembl biotype	miRNA
Entrez	100422938
RNAcentral	URS000075AADA — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582487

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582487 — 1 exons

Exon	Start	End
ENSE00002700517	160474402	160474483

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 80.21.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	80.21	gold quality
monocyte	CL:0000576	79.79	gold quality
blood	UBERON:0000178	77.79	gold quality
kidney	UBERON:0002113	76.24	gold quality
lung	UBERON:0002048	73.47	gold quality
endometrium	UBERON:0001295	72.78	gold quality
lymph node	UBERON:0000029	70.82	gold quality
minor salivary gland	UBERON:0001830	66.65	gold quality
gall bladder	UBERON:0002110	66.52	gold quality
Ammon’s horn	UBERON:0001954	64.99	gold quality
right atrium auricular region	UBERON:0006631	64.89	gold quality
stomach	UBERON:0000945	64.52	gold quality
skin of abdomen	UBERON:0001416	64.27	gold quality
colon	UBERON:0001155	64.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.50	gold quality
testis	UBERON:0000473	63.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.77	gold quality
anterior cingulate cortex	UBERON:0009835	62.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.39	gold quality
body of stomach	UBERON:0001161	62.33	gold quality
left lobe of thyroid gland	UBERON:0001120	62.07	gold quality
esophagus mucosa	UBERON:0002469	62.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.83	gold quality
tibial nerve	UBERON:0001323	61.60	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.38	gold quality
prostate gland	UBERON:0002367	61.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.85	gold quality
omental fat pad	UBERON:0010414	60.30	gold quality
transverse colon	UBERON:0001157	60.13	gold quality
spleen	UBERON:0002106	60.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• serum miR-3142 in cervical cancer is increased and is closely related to the occurrence and development of cervical cancer (PMID:30969093)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.