MIR3143

Summary

MIR3143 (microRNA 3143, HGNC:38284) is a microRNA gene on chromosome 6p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422934 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38284
Approved symbol	MIR3143
Name	microRNA 3143
Location	6p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3143
Ensembl gene	ENSG00000265565
Ensembl biotype	miRNA
Entrez	100422934
RNAcentral	URS0000759A9E — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584253

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584253 — 1 exons

Exon	Start	End
ENSE00002710443	27147626	27147688

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 83.81.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	83.81	gold quality
adrenal tissue	UBERON:0018303	78.89	gold quality
calcaneal tendon	UBERON:0003701	78.42	gold quality
blood	UBERON:0000178	77.93	gold quality
monocyte	CL:0000576	76.73	gold quality
stomach	UBERON:0000945	76.03	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.78	gold quality
heart	UBERON:0000948	73.25	gold quality
heart left ventricle	UBERON:0002084	71.96	gold quality
right uterine tube	UBERON:0001302	71.92	gold quality
right ovary	UBERON:0002118	71.43	gold quality
body of pancreas	UBERON:0001150	71.31	gold quality
lung	UBERON:0002048	71.02	gold quality
right lobe of liver	UBERON:0001114	70.61	gold quality
endometrium	UBERON:0001295	69.87	gold quality
left adrenal gland cortex	UBERON:0035825	69.65	gold quality
pituitary gland	UBERON:0000007	69.46	gold quality
intestine	UBERON:0000160	69.27	gold quality
right atrium auricular region	UBERON:0006631	69.20	gold quality
body of stomach	UBERON:0001161	69.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.00	gold quality
left coronary artery	UBERON:0001626	68.49	gold quality
small intestine	UBERON:0002108	68.08	gold quality
thoracic aorta	UBERON:0001515	67.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.78	gold quality
colon	UBERON:0001155	67.36	gold quality
transverse colon	UBERON:0001157	67.21	gold quality
right adrenal gland cortex	UBERON:0035827	67.14	gold quality
ascending aorta	UBERON:0001496	67.13	gold quality
tibial artery	UBERON:0007610	67.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.