MIR3144

Summary

MIR3144 (microRNA 3144, HGNC:38331) is a microRNA gene on chromosome 6q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422951 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38331
Approved symbol	MIR3144
Name	microRNA 3144
Location	6q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3144
Ensembl gene	ENSG00000265725
Ensembl biotype	miRNA
Entrez	100422951
RNAcentral	URS000075EF28 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579460

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579460 — 1 exons

Exon	Start	End
ENSE00002707230	120015179	120015257

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 83.07.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	83.07	gold quality
blood	UBERON:0000178	78.38	gold quality
lung	UBERON:0002048	75.57	gold quality
monocyte	CL:0000576	72.28	gold quality
stomach	UBERON:0000945	70.21	gold quality
intestine	UBERON:0000160	65.55	gold quality
body of stomach	UBERON:0001161	64.94	gold quality
esophagus mucosa	UBERON:0002469	64.63	gold quality
tibial artery	UBERON:0007610	64.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.09	gold quality
nucleus accumbens	UBERON:0001882	62.62	gold quality
thyroid gland	UBERON:0002046	62.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.37	gold quality
vagina	UBERON:0000996	61.94	gold quality
right frontal lobe	UBERON:0002810	59.45	gold quality
liver	UBERON:0002107	58.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.45	gold quality
thoracic mammary gland	UBERON:0005200	57.42	gold quality
colon	UBERON:0001155	55.59	gold quality
hypothalamus	UBERON:0001898	54.74	gold quality
left testis	UBERON:0004533	35.67	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Data show that the site targeted by two microRNAs, miR-875 and miR-3144 is located in HPV16 E6 oncogene open reading frame (ORF). (PMID:25913515)
• In silico analysis suggested that rs1972820 located in the 3’UTR of ERBB4 gene affects the binding affinity of miR-3144-3p a potential oncomiRNA. Statistical analysis showed a significant association between SNP rs1972820 G allele and reduced breast cancer risk, odds ratio = 0.443 (95% CI: 0.196-0.998). (PMID:28508829)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.