MIR3145

Summary

MIR3145 (microRNA 3145, HGNC:38327) is a microRNA gene on chromosome 6q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423001 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38327
Approved symbol	MIR3145
Name	microRNA 3145
Location	6q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3145
Ensembl gene	ENSG00000266555
Ensembl biotype	miRNA
Entrez	100423001
RNAcentral	URS000075B68C — miRNA, 82 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580727

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580727 — 1 exons

Exon	Start	End
ENSE00002715991	138435213	138435294

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 81.54.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	81.54	gold quality
blood	UBERON:0000178	81.34	gold quality
bone marrow	UBERON:0002371	81.01	gold quality
adrenal tissue	UBERON:0018303	79.31	gold quality
endometrium	UBERON:0001295	78.93	gold quality
calcaneal tendon	UBERON:0003701	76.52	gold quality
placenta	UBERON:0001987	75.39	gold quality
liver	UBERON:0002107	75.32	gold quality
gastrocnemius	UBERON:0001388	74.02	gold quality
stomach	UBERON:0000945	73.76	gold quality
kidney	UBERON:0002113	73.25	gold quality
heart	UBERON:0000948	73.01	gold quality
monocyte	CL:0000576	72.59	gold quality
heart left ventricle	UBERON:0002084	72.39	gold quality
islet of Langerhans	UBERON:0000006	71.78	gold quality
rectum	UBERON:0001052	71.45	gold quality
intestine	UBERON:0000160	71.33	gold quality
right lobe of liver	UBERON:0001114	71.13	gold quality
body of pancreas	UBERON:0001150	71.00	gold quality
body of stomach	UBERON:0001161	70.70	gold quality
small intestine	UBERON:0002108	70.45	gold quality
colon	UBERON:0001155	70.27	gold quality
lung	UBERON:0002048	70.22	gold quality
transverse colon	UBERON:0001157	70.14	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.03	gold quality
adult mammalian kidney	UBERON:0000082	69.85	gold quality
right atrium auricular region	UBERON:0006631	68.99	gold quality
mucosa of stomach	UBERON:0001199	68.42	gold quality
left coronary artery	UBERON:0001626	67.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.