MIR3146

Summary

MIR3146 (microRNA 3146, HGNC:38368) is a microRNA gene on chromosome 7p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422967 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38368
Approved symbol	MIR3146
Name	microRNA 3146
Location	7p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3146
Ensembl gene	ENSG00000265932
Ensembl biotype	miRNA
Entrez	100422967
RNAcentral	URS000075BE4B — miRNA, 79 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580367

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580367 — 1 exons

Exon	Start	End
ENSE00002723713	19705358	19705436

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 84.19.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	84.19	gold quality
endometrium	UBERON:0001295	80.45	gold quality
lymph node	UBERON:0000029	79.67	gold quality
adrenal tissue	UBERON:0018303	77.45	gold quality
monocyte	CL:0000576	76.27	gold quality
rectum	UBERON:0001052	73.74	gold quality
blood	UBERON:0000178	73.51	gold quality
calcaneal tendon	UBERON:0003701	73.04	gold quality
gastrocnemius	UBERON:0001388	73.02	gold quality
endocervix	UBERON:0000458	71.88	gold quality
placenta	UBERON:0001987	71.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.35	gold quality
adult mammalian kidney	UBERON:0000082	70.03	gold quality
stomach	UBERON:0000945	69.67	gold quality
kidney	UBERON:0002113	69.31	gold quality
heart left ventricle	UBERON:0002084	69.29	gold quality
left coronary artery	UBERON:0001626	69.18	gold quality
body of pancreas	UBERON:0001150	69.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.90	gold quality
adrenal gland	UBERON:0002369	68.20	gold quality
tibial artery	UBERON:0007610	68.01	gold quality
heart	UBERON:0000948	67.78	gold quality
right lobe of liver	UBERON:0001114	67.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.46	gold quality
skin of abdomen	UBERON:0001416	67.21	gold quality
body of stomach	UBERON:0001161	67.03	gold quality
ascending aorta	UBERON:0001496	66.92	gold quality
ectocervix	UBERON:0012249	66.77	gold quality
fallopian tube	UBERON:0003889	66.71	gold quality
omental fat pad	UBERON:0010414	66.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-3146 induces neutrophil extracellular traps to aggravate gout flare. (PMID:34606644)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.