MIR3147

Summary

MIR3147 (microRNA 3147, HGNC:38300) is a microRNA gene on chromosome 7p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422939 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38300
Approved symbol	MIR3147
Name	microRNA 3147
Location	7p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3147
Ensembl gene	ENSG00000266168
Ensembl biotype	miRNA
Entrez	100422939
RNAcentral	URS000075D81C — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577811 — 1 exons

Exon	Start	End
ENSE00002699852	57405025	57405090

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 73.08.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.08	gold quality
right atrium auricular region	UBERON:0006631	70.99	gold quality
heart left ventricle	UBERON:0002084	70.27	gold quality
body of pancreas	UBERON:0001150	69.36	gold quality
left adrenal gland	UBERON:0001234	68.42	gold quality
left coronary artery	UBERON:0001626	67.52	gold quality
left adrenal gland cortex	UBERON:0035825	65.94	gold quality
tibial artery	UBERON:0007610	64.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.86	gold quality
omental fat pad	UBERON:0010414	61.22	gold quality
spleen	UBERON:0002106	59.54	gold quality
vagina	UBERON:0000996	56.38	gold quality
testis	UBERON:0000473	43.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• the results indicated that miR3147 may serve an oncogenic role in vulvar squamous cell carcinoma (VSCC) by targeting Smad4. miR3147 may represent a novel potential therapeutic target marker for VSCC. (PMID:29512734)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.